Parp6 MGI Mouse Gene Detail - MGI:1914537 - poly (ADP-ribose) polymerase family, member 6

Symbol

Parp6
Name

poly (ADP-ribose) polymerase family, member 6
Synonyms

1700119G14Rik, 2310028P13Rik, 3110038K10Rik, C030013N01Rik

Feature Type

protein coding gene
IDs

MGI:1914537
NCBI Gene: 67287
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr9:59524567-59557568 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 32.02 cM, cytoband C
Mapping Data

2 experiments

SNPs within 2kb

577 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914537	protein coding gene	Chr9:59524473-59557573 (+)
129S1/SvImJ	ENSMUSG00200035069	protein coding gene	Chr9:56643421-56676587 (+)
A/J	ENSMUSG00195036822	protein coding gene	Chr9:56350583-56383705 (+)
AKR/J	ENSMUSG00220024358	protein coding gene	Chr9:56500356-56533484 (+)
BALB/cJ	ENSMUSG00180017276	protein coding gene	Chr9:56465357-56498489 (+)
C3H/HeJ	ENSMUSG00175019147	protein coding gene	Chr9:56477237-56510358 (+)
C57BL/6NJ	ENSMUSG00215018977	protein coding gene	Chr9:56458618-56491743 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032306	protein coding gene	Chr9:56818522-56850664 (+)
CAST/EiJ	ENSTCUG00005020524	protein coding gene	Chr9:56393699-56427069 (+)
CBA/J	ENSMUSG00210036184	protein coding gene	Chr9:56582123-56615225 (+)
DBA/2J	ENSMUSG00185039186	protein coding gene	Chr9:56604018-56637135 (+)
FVB/NJ	ENSMUSG00205030310	protein coding gene	Chr9:56919841-56952961 (+)
JF1/MsJ	ENSUMUG00000039721	protein coding gene	Chr9:56622640-56656164 (+)
LP/J	ENSMUSG00230038057	protein coding gene	Chr9:56843000-56876166 (+)
NOD/ShiLtJ	ENSMUSG00190037148	protein coding gene	Chr9:56674150-56707270 (+)
NZO/HlLtJ	ENSMUSG00225027237	protein coding gene	Chr9:56892030-56925195 (+)
PWK/PhJ	ENSLUMG00010030379	protein coding gene	Chr9:56577540-56611167 (+)
SPRET/EiJ	ENSMSPG00010021133	protein coding gene	Chr9:57628700-57656429 (+)
WSB/EiJ	ENSIUOG00005038645	protein coding gene	Chr9:56081780-56114918 (+)

Human Ortholog

PARP6, poly(ADP-ribose) polymerase family member 6

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PARP6, poly(ADP-ribose) polymerase family member 6
Synonyms

ARTD17, PARP-6-B1, PARP-6-C, pART17
Links

HGNC:26921

NCBI Gene ID: 56965

UniProt: Q2NL67
Chr Location

15q23; chr15:72241176-72272999 (-) GRCh38

MGI Vertebrate Homology

Parp6 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PARP6
Gene Tree

Parp6

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

5
Gene trapped

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mice with an allele devoid of catalytic activity die shortly after birth with cyanosis and less air in lungs. A small percentage survive to at least P21, are smaller, have erratic and jumpy behavior and one male surviving to adulthood is sterile.

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All GO Annotations

17
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

720
Tissues

25
cDNA Data

62
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase parp6

ZFIN parp6a

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All Sequences

123
RefSeq

58
UniProt

8
CCDS

CCDS57680.1, CCDS90586.1

Ensembl

ENSMUSG00000025237 (Evidence)
NCBI Gene

67287

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025237	Ensembl Gene Model \| MGI Sequence Detail	33002	C57BL/6J	± kb
transcript	ENSMUST00000026267	Ensembl \| MGI Sequence Detail	2709	Not Applicable
polypeptide	ENSMUSP00000026267	Ensembl \| MGI Sequence Detail	630	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000012299 protein mono-ADP-ribosyltransferase PARP6

(term hierarchy)
EC

2.4.2.-
InterPro Domains

IPR051838 Intracellular mono-ADP-ribosyltransferase ARTD/PARP

IPR063425 PARP6/PARP8, N-terminal domain

IPR012317 Poly(ADP-ribose) polymerase, catalytic domain
GlyGen

Q6P6P7 1 site

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All nucleic 63

cDNA 62

Primer pair 1

Microarray probesets 6

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MGI:1917528, MGI:1920873, MGI:1924773

Summaries

All 41

Developmental Gene Expression 8

Gene Ontology 6

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Parp6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr85445	Chr9:59524521-59524565 (+)	-24 bp
Tssr85446	Chr9:59524567-59524584 (+)	9 bp
Tssr85447	Chr9:59524585-59524661 (+)	56 bp
Tssr85448	Chr9:59525551-59525555 (+)	986 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24