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Ndufb8 Gene Detail
Summary
  • Symbol
    Ndufb8
  • Name
    NADH:ubiquinone oxidoreductase subunit B8
  • Synonyms
    2900010I05Rik
Location &
Maps
more
  • Sequence Map
    Chr19:44537011-44543879 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 37.98 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    340 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914514
 protein coding gene Chr19:44537010-44543881 (-)
129S1/SvImJ ENSMUSG00200021484
 protein coding gene Chr19:41251732-41258600 (-)
A/J ENSMUSG00195014175
 protein coding gene Chr19:41385427-41392295 (-)
AKR/J ENSMUSG00220019285
 protein coding gene Chr19:41179278-41186146 (-)
BALB/cJ ENSMUSG00180016653
 protein coding gene Chr19:41637804-41644672 (-)
C3H/HeJ ENSMUSG00175005964
 protein coding gene Chr19:41168250-41175118 (-)
C57BL/6NJ ENSMUSG00215004233
 protein coding gene Chr19:41227330-41234198 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023002
 protein coding gene Chr19:41210937-41218037 (-)
CAST/EiJ ENSTCUG00005016077
 protein coding gene Chr19:40821465-40828342 (-)
CBA/J ENSMUSG00210018865
 protein coding gene Chr19:41247919-41254787 (-)
DBA/2J ENSMUSG00185007500
 protein coding gene Chr19:41761450-41768318 (-)
FVB/NJ ENSMUSG00205016686
 protein coding gene Chr19:40675293-40682161 (-)
JF1/MsJ ENSUMUG00000038534
 protein coding gene Chr19:41905032-41911905 (-)
LP/J ENSMUSG00230021949
 protein coding gene Chr19:42521671-42528539 (-)
NOD/ShiLtJ ENSMUSG00190004907
 protein coding gene Chr19:41111201-41118069 (-)
NZO/HlLtJ ENSMUSG00225044076
 protein coding gene Chr19:46116096-46122979 (-)
PWK/PhJ ENSLUMG00010001040
 protein coding gene Chr19:41069725-41076603 (-)
SPRET/EiJ ENSMSPG00010007605
 protein coding gene Chr19:40813257-40819534 (-)
WSB/EiJ ENSIUOG00005005595
 protein coding gene Chr19:40621260-40628128 (-)



Homology
more
  • Human Ortholog
    NDUFB8, NADH:ubiquinone oxidoreductase subunit B8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NDUFB8, NADH:ubiquinone oxidoreductase subunit B8
  • Synonyms
    ASHI, CI-ASHI, MC1DN32
  • Links
    NCBI Gene ID: 4714
    UniProt: O95169

  • Chr Location
    10q24.31; chr10:100523668-100530000 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NDUFB8 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal trophoblast layer formation and complete embryonic lethality during organogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    12
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    854
  • Tissues
    111
  • cDNA Data
    245
  • Literature Summary
    31
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025204 Ensembl Gene Model | MGI Sequence Detail 6869 C57BL/6J ±  kb
transcript ENSMUST00000026222 Ensembl | MGI Sequence Detail 680 Not Applicable  
polypeptide ENSMUSP00000026222 Ensembl | MGI Sequence Detail 186 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 247
    cDNA 245
    Primer pair 2
    Antibodies 4

    Microarray probesets 6
Other
Accession IDs
less
MGI:2147623
References
more
  • Summaries
    All 81
    Developmental Gene Expression 31
    Gene Ontology 12
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:391317 Alsina D, et al., Pathogenic POLRMT variants in mice impair mtDNA transcription and affect perinatal survival. JCI Insight. 2026 Jul 22;11(14)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory