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Tbc1d20 Gene Detail
Summary
  • Symbol
    Tbc1d20
  • Name
    TBC1 domain family, member 20
  • Synonyms
    1110028I04Rik, 2810442O16Rik, bs
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914481
    NCBI Gene: 67231
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:152135748-152155916 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 74.83 cM, cytoband H1
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    416 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914481
 protein coding gene Chr2:152135745-152155916 (+)
129S1/SvImJ ENSMUSG00200029790
 protein coding gene Chr2:149037567-149057723 (+)
A/J ENSMUSG00195020684
 protein coding gene Chr2:149320686-149340854 (+)
AKR/J ENSMUSG00220044839
 protein coding gene Chr2:148644197-148664368 (+)
BALB/cJ ENSMUSG00180041292
 protein coding gene Chr2:148805725-148825897 (+)
C3H/HeJ ENSMUSG00175038453
 protein coding gene Chr2:149551943-149572113 (+)
C57BL/6NJ ENSMUSG00215018976
 protein coding gene Chr2:148978917-148999087 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024449
 protein coding gene Chr2:144168099-144188793 (+)
CAST/EiJ ENSTCUG00005042067
 protein coding gene Chr2:147896202-147916863 (+)
CBA/J ENSMUSG00210043643
 protein coding gene Chr2:149488457-149508627 (+)
DBA/2J ENSMUSG00185043991
 protein coding gene Chr2:149138922-149159090 (+)
FVB/NJ ENSMUSG00205022587
 protein coding gene Chr2:148235660-148255829 (+)
JF1/MsJ ENSUMUG00000045185
 protein coding gene Chr2:148809823-148830200 (+)
LP/J ENSMUSG00230031874
 protein coding gene Chr2:150789983-150810140 (+)
NOD/ShiLtJ ENSMUSG00190029698
 protein coding gene Chr2:148909296-148929673 (+)
NZO/HlLtJ ENSMUSG00225004369
 protein coding gene Chr2:158827070-158847238 (+)
PWK/PhJ ENSLUMG00010036717
 protein coding gene Chr2:148779407-148799566 (+)
SPRET/EiJ ENSMSPG00010026757
 protein coding gene Chr2:151505278-151525495 (+)
WSB/EiJ ENSIUOG00005046461
 protein coding gene Chr2:148644917-148665086 (+)



Homology
more
  • Human Ortholog
    TBC1D20, TBC1 domain family member 20
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TBC1D20, TBC1 domain family member 20
  • Synonyms
    C20orf140, WARBM4
  • Links
    NCBI Gene ID: 128637
    UniProt: Q96BZ9

  • Chr Location
    20p13; chr20:423596-462566 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tbc1d20 mouse models; 1 with human TBC1D20 associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 3 alleles in 4 genetic backgrounds
    1 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants have bilateral cataracts, small eyes, glossy coats, and are male sterile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027465 Ensembl Gene Model | MGI Sequence Detail 20169 C57BL/6J ±  kb
    transcript ENSMUST00000028963 Ensembl | MGI Sequence Detail 3386 Not Applicable  
    polypeptide ENSMUSP00000028963 Ensembl | MGI Sequence Detail 402 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 17

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-1673, MGI:1923567, MGI:2138929, MGI:88207
    References
    more
    • Summaries
      All 48
      Diseases 2
      Gene Ontology 9
      Phenotypes 19
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory