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Dph7 Gene Detail
Summary
  • Symbol
    Dph7
  • Name
    diphthamine biosynethesis 7
  • Synonyms
    2810443J12Rik, Wdr85
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914478
    NCBI Gene: 67228
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:24852412-24862175 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 16.87 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    413 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914478
 protein coding gene Chr2:24852183-24862198 (+)
129S1/SvImJ ENSMUSG00200051516
 protein coding gene Chr2:21836545-21846309 (+)
A/J ENSMUSG00195042833
 protein coding gene Chr2:21927440-21937190 (+)
AKR/J ENSMUSG00220053012
 protein coding gene Chr2:22045291-22055043 (+)
BALB/cJ ENSMUSG00180051592
 protein coding gene Chr2:21938173-21947936 (+)
C3H/HeJ ENSMUSG00175046969
 protein coding gene Chr2:21902379-21912142 (+)
C57BL/6NJ ENSMUSG00215047092
 protein coding gene Chr2:21961047-21970811 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023243
 protein coding gene Chr2:20855482-20865341 (+)
CAST/EiJ ENSTCUG00005053014
 protein coding gene Chr2:21679774-21689993 (+)
CBA/J ENSMUSG00210016009
 protein coding gene Chr2:21941353-21951117 (+)
DBA/2J ENSMUSG00185052437
 protein coding gene Chr2:21841727-21851476 (+)
FVB/NJ ENSMUSG00205048161
 protein coding gene Chr2:21694724-21704478 (+)
JF1/MsJ ENSUMUG00000054983
 protein coding gene Chr2:21753973-21764056 (+)
LP/J ENSMUSG00230037568
 protein coding gene Chr2:23772565-23782328 (+)
NOD/ShiLtJ ENSMUSG00190030092
 protein coding gene Chr2:21932854-21942617 (+)
NZO/HlLtJ ENSMUSG00225010101
 protein coding gene Chr2:31523222-31532989 (+)
PWK/PhJ ENSLUMG00010040281
 protein coding gene Chr2:21849407-21859532 (+)
SPRET/EiJ ENSMSPG00010030195
 protein coding gene Chr2:22537821-22548444 (+)
WSB/EiJ ENSIUOG00005050479
 protein coding gene Chr2:21797886-21807635 (+)



Homology
more
  • Human Ortholog
    DPH7, diphthamide biosynthesis 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DPH7, diphthamide biosynthesis 7
  • Synonyms
    C9orf112, RRT2, WDR85
  • Links
    NCBI Gene ID: 92715
    UniProt: Q9BTV6

  • Chr Location
    9q34.3; chr9:137554444-137578925 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    12
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026975 Ensembl Gene Model | MGI Sequence Detail 9764 C57BL/6J ±  kb
transcript ENSMUST00000028351 Ensembl | MGI Sequence Detail 1666 Not Applicable  
polypeptide ENSMUSP00000028351 Ensembl | MGI Sequence Detail 477 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 8
Other
Accession IDs
less
MGI:2139288
References
more
  • Summaries
    All 35
    Gene Ontology 9
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:354401 Wei H, et al., A modified form of diphthamide causes immunotoxin resistance in a lymphoma cell line with a deletion of the WDR85 gene. J Biol Chem. 2013 Apr 26;288(17):12305-12
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory