Eif4e2 MGI Mouse Gene Detail - MGI:1914440 - eukaryotic translation initiation factor 4E member 2

Symbol

Eif4e2
Name

eukaryotic translation initiation factor 4E member 2
Synonyms

2700069E09Rik, D0H0S6743E, Eif4el3

Feature Type

protein coding gene
IDs

MGI:1914440
NCBI Gene: 26987
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr1:87141636-87168210 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 44.08 cM, cytoband C5
Mapping Data

3 experiments

SNPs within 2kb

583 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914440	protein coding gene	Chr1:87141633-87168210 (+)
129S1/SvImJ	ENSMUSG00200037286	protein coding gene	Chr1:84382313-84408925 (+)
A/J	ENSMUSG00195028962	protein coding gene	Chr1:83942758-83969371 (+)
AKR/J	ENSMUSG00220042351	protein coding gene	Chr1:84061285-84087861 (+)
BALB/cJ	ENSMUSG00180014724	protein coding gene	Chr1:84230735-84257312 (+)
C3H/HeJ	ENSMUSG00175001342	protein coding gene	Chr1:84117177-84143791 (+)
C57BL/6NJ	ENSMUSG00215028129	protein coding gene	Chr1:84032626-84059204 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014377	protein coding gene	Chr1:79691692-79718850 (+)
CAST/EiJ	ENSTCUG00005006660	protein coding gene	Chr1:83674696-83701439 (+)
CBA/J	ENSMUSG00210011896	protein coding gene	Chr1:83955007-83981584 (+)
DBA/2J	ENSMUSG00185016517	protein coding gene	Chr1:88427110-88453718 (+)
FVB/NJ	ENSMUSG00205029438	protein coding gene	Chr1:83376801-83403410 (+)
JF1/MsJ	ENSUMUG00000013455	protein coding gene	Chr1:87182246-87208828 (+)
LP/J	ENSMUSG00230019980	protein coding gene	Chr1:87711866-87738475 (+)
NOD/ShiLtJ	ENSMUSG00190022132	protein coding gene	Chr1:84010247-84036822 (+)
NZO/HlLtJ	ENSMUSG00225004071	protein coding gene	Chr1:91614577-91641186 (+)
PWK/PhJ	ENSLUMG00010044934	protein coding gene	Chr1:83564585-83591111 (+)
SPRET/EiJ	ENSMSPG00010041804	protein coding gene	Chr1:85580832-85606167 (+)
WSB/EiJ	ENSIUOG00005038782	protein coding gene	Chr1:83605305-83631900 (+)

Human Ortholog

EIF4E2, eukaryotic translation initiation factor 4E family member 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EIF4E2, eukaryotic translation initiation factor 4E family member 2
Synonyms

4EHP, 4E-LP, EIF4EL3, h4EHP, IF4e
Links

HGNC:3293

NCBI Gene ID: 9470

UniProt: O60573
Chr Location

2q37.1; chr2:232550659-232583644 (+) GRCh38

MGI Vertebrate Homology

Eif4e2 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: EIF4E2
Gene Tree

Eif4e2

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

169
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

164
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Eif4e2
Find Mice (IMSR)

93 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display complete neonatal lethality, cyanosis, decreased birth weight and decreased brain size.

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All GO Annotations

27
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

621
Tissues

12
cDNA Data

14
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase eif4e2, LOC548830

ZFIN eif4e2

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All Sequences

92
RefSeq

23
UniProt

12
CCDS

CCDS15130.1, CCDS15131.1, CCDS35652.1, CCDS83571.1

Ensembl

ENSMUSG00000026254 (Evidence)
NCBI Gene

26987

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026254	Ensembl Gene Model \| MGI Sequence Detail	26575	C57BL/6J	± kb
transcript	ENSMUST00000050876	Ensembl \| MGI Sequence Detail	2869	Not Applicable
polypeptide	ENSMUSP00000053403	Ensembl \| MGI Sequence Detail	259	Not Applicable

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UniProt

12 Sequences
Protein Ontology

PR:000006992 eukaryotic translation initiation factor 4E type 2

(term hierarchy)
InterPro Domains

IPR019770 Eukaryotic translation initiation factor 4E (eIF-4E), conserved site

IPR001040 Translation Initiation factor eIF- 4e

IPR023398 Translation Initiation factor eIF- 4e-like

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All nucleic 18

cDNA 16

Primer pair 2

Antibodies 1

Microarray probesets 5

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MGD-MRK-31050, MGI:104977, MGI:2138147, MGI:2138520

Summaries

All 57

Developmental Gene Expression 7

Gene Ontology 7

Phenotypes 17
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:389045 Ladak RJ, et al., The 4EHP-mediated translational repression of cGAS impedes the host immune response against DNA viruses. Proc Natl Acad Sci U S A. 2024 Nov 26;121(48):e2413018121

TSS for Eif4e2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7828	Chr1:87141631-87141640 (+)	0 bp
Tssr7829	Chr1:87141646-87141712 (+)	43 bp
Tssr7830	Chr1:87141781-87141790 (+)	150 bp
Tssr7831	Chr1:87142023-87142091 (+)	421 bp
Tssr7832	Chr1:87142098-87142111 (+)	469 bp
Tssr7833	Chr1:87153633-87153660 (+)	12,011 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24