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Ccdc159 Gene Detail
Summary
  • Symbol
    Ccdc159
  • Name
    coiled-coil domain containing 159
  • Synonyms
    2510048L02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914369
    NCBI Gene: 67119
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:21838767-21847168 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 7.92 cM, cytoband A4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    240 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914369
 protein coding gene Chr9:21838767-21847168 (+)
129S1/SvImJ ENSMUSG00200048606
 protein coding gene Chr9:18793011-18801413 (+)
A/J ENSMUSG00195033636
 protein coding gene Chr9:18629651-18638052 (+)
AKR/J ENSMUSG00220031389
 protein coding gene Chr9:18632077-18640478 (+)
BALB/cJ ENSMUSG00180039414
 protein coding gene Chr9:18763940-18772342 (+)
C3H/HeJ ENSMUSG00175036672
 protein coding gene Chr9:18726477-18734878 (+)
C57BL/6NJ ENSMUSG00215036050
 protein coding gene Chr9:18723774-18732175 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031887
 protein coding gene Chr9:17931131-17939778 (+)
CAST/EiJ ENSTCUG00005030994
 protein coding gene Chr9:18770371-18778796 (+)
CBA/J ENSMUSG00210036702
 protein coding gene Chr9:18707406-18715811 (+)
DBA/2J ENSMUSG00185024565
 protein coding gene Chr9:18822710-18831111 (+)
FVB/NJ ENSMUSG00205033515
 protein coding gene Chr9:19058705-19067137 (+)
JF1/MsJ ENSUMUG00000043499
 protein coding gene Chr9:18923981-18932409 (+)
LP/J ENSMUSG00230037915
 protein coding gene Chr9:19217906-19226336 (+)
NOD/ShiLtJ ENSMUSG00190030987
 protein coding gene Chr9:18751678-18760110 (+)
NZO/HlLtJ ENSMUSG00225047892
 protein coding gene Chr9:19164678-19173079 (+)
PWK/PhJ ENSLUMG00010038801
 protein coding gene Chr9:18814938-18823572 (+)
SPRET/EiJ ENSMSPG00010018580
 protein coding gene Chr9:19042529-19051155 (+)
WSB/EiJ ENSIUOG00005044122
 protein coding gene Chr9:18293605-18302041 (+)



Homology
more
  • Human Ortholog
    CCDC159, coiled-coil domain containing 159
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCDC159, coiled-coil domain containing 159
  • Links
    NCBI Gene ID: 126075
    UniProt: P0C7I6

  • Chr Location
    19p13.2; chr19:11344684-11354944 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ccdc159 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a null allele display infertility, failure of sperm connecting piece formation, and disconnected sperm tails.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67119 NCBI Gene Model | MGI Sequence Detail 8402 C57BL/6J ±  kb
    transcript NM_001164614 RefSeq | MGI Sequence Detail 1545 C57BL/6  
    polypeptide Q8C963 UniProt | EBI | MGI Sequence Detail 411 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 3
    References
    more
    • Summaries
      All 30
      Diseases 1
      Gene Ontology 1
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:351297 Ge T, et al., Coiled-coil domain containing 159 is required for spermatid head and tail assembly in mice. Biol Reprod. 2024 May 9;110(5):877-894
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory