Cuedc2 MGI Mouse Gene Detail - MGI:1914366

Symbol

Cuedc2
Name

CUE domain containing 2
Synonyms

3010002G01Rik

Feature Type

protein coding gene
IDs

MGI:1914366
NCBI Gene: 67116
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr19:46318251-46327141 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 38.81 cM, cytoband D1
Mapping Data

2 experiments

SNPs within 2kb

293 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914366	protein coding gene	Chr19:46318251-46327144 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025206	protein coding gene	Chr19:46010785-46019650 (-)
A/J	MGP_AJ_G0025182	protein coding gene	Chr19:43746560-43755412 (-)
AKR/J	MGP_AKRJ_G0025151	protein coding gene	Chr19:45163470-45172326 (-)
BALB/cJ	MGP_BALBcJ_G0025177	protein coding gene	Chr19:43805459-43814323 (-)
C3H/HeJ	MGP_C3HHeJ_G0024937	protein coding gene	Chr19:45331128-45340008 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025620	protein coding gene	Chr19:47162564-47171412 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023034	protein coding gene	Chr19:42985290-42993799 (-)
CAST/EiJ	MGP_CASTEiJ_G0024402	protein coding gene	Chr19:45131230-45140166 (-)
CBA/J	MGP_CBAJ_G0024917	protein coding gene	Chr19:49517493-49526376 (-)
DBA/2J	MGP_DBA2J_G0025049	protein coding gene	Chr19:43570022-43578883 (-)
FVB/NJ	MGP_FVBNJ_G0025010	protein coding gene	Chr19:43346977-43355837 (-)
LP/J	MGP_LPJ_G0025135	protein coding gene	Chr19:45921498-45930361 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025041	protein coding gene	Chr19:48859886-48868749 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025678	protein coding gene	Chr19:45271220-45280074 (-)
PWK/PhJ	MGP_PWKPhJ_G0024151	protein coding gene	Chr19:43516462-43525316 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023955	protein coding gene	Chr19:43924639-43932818 (-)
WSB/EiJ	MGP_WSBEiJ_G0024472	protein coding gene	Chr19:45412824-45421678 (-)

Human Ortholog

CUEDC2, CUE domain containing 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CUEDC2, CUE domain containing 2
Synonyms

bA18I14.5, C10orf66
Links

HGNC:28352

NCBI Gene ID: 79004

neXtProt AC: NX_Q9H467

UniProt: Q9H467
Chr Location

10q24.32; chr10:102423245-102432584 (-) GRCh38

MGI Vertebrate Homology

Cuedc2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CUEDC2
Gene Tree

Cuedc2

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

1
Gene trapped

13
Targeted

2
Incidental Mutations

APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice show increased susceptibility to DSS-induced colitis and colitis-associated colon cancer, and increased macrophage proinflammatory cytokine production in response to LPS.

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All GO Annotations

19
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

3
cDNA Data

86
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cuedc2

ZFIN cuedc2

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All Sequences

139
RefSeq

64
UniProt

9
CCDS

CCDS29876.1, CCDS89409.1, CCDS89410.1

Ensembl

ENSMUSG00000036748 (Evidence)
NCBI Gene

67116

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036748	Ensembl Gene Model \| MGI Sequence Detail	8891	C57BL/6J	± kb
transcript	ENSMUST00000167861	Ensembl \| MGI Sequence Detail	1941	Not Applicable
polypeptide	ENSMUSP00000129589	Ensembl \| MGI Sequence Detail	284	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000006044 CUE domain-containing protein 2

(term hierarchy)
InterPro Domains

IPR039805 CUE domain-containing protein 2, CUE domain

IPR003892 Ubiquitin system component CUE

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All nucleic 86

cDNA 86

Microarray probesets 4

Summaries

All 35

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:329215 Jian Z, et al., CUEDC2 modulates cardiomyocyte oxidative capacity by regulating GPX1 stability. EMBO Mol Med. 2016 Jul;8(7):813-29

TSS for Cuedc2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr159643	Chr19:46327071-46327109 (-)	51 bp
Tssr159642	Chr19:46327028-46327069 (-)	92 bp
Tssr159641	Chr19:46326813-46326842 (-)	313 bp
Tssr159640	Chr19:46321353-46321367 (-)	5,781 bp
Tssr159639	Chr19:46321309-46321342 (-)	5,815 bp
Tssr159638	Chr19:46321238-46321249 (-)	5,897 bp
Tssr159637	Chr19:46321215-46321230 (-)	5,918 bp
Tssr159636	Chr19:46321134-46321147 (-)	6,000 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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