Pgp MGI Mouse Gene Detail - MGI:1914328 - phosphoglycolate phosphatase

Symbol

Pgp
Name

phosphoglycolate phosphatase
Synonyms

1700012G19Rik

Feature Type

protein coding gene
IDs

MGI:1914328
NCBI Gene: 67078
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr17:24689400-24692084 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 12.39 cM, cytoband A3.3
Mapping Data

3 experiments

SNPs within 2kb

129 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914328	protein coding gene	Chr17:24689366-24692084 (+)
129S1/SvImJ	ENSMUSG00200052015	protein coding gene	Chr17:20135676-20138396 (+)
A/J	ENSMUSG00195048580	protein coding gene	Chr17:21154504-21157224 (+)
AKR/J	ENSMUSG00220024885	protein coding gene	Chr17:20200881-20203598 (+)
BALB/cJ	ENSMUSG00180032758	protein coding gene	Chr17:20428107-20430823 (+)
C3H/HeJ	ENSMUSG00175048703	protein coding gene	Chr17:20186519-20189235 (+)
C57BL/6NJ	ENSMUSG00215049571	protein coding gene	Chr17:20197341-20200059 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021186	protein coding gene	Chr17:20290492-20291616 (+)
CAST/EiJ	ENSTCUG00005050128	protein coding gene	Chr17:20767505-20770229 (+)
CBA/J	ENSMUSG00210035424	protein coding gene	Chr17:20025344-20028060 (+)
DBA/2J	ENSMUSG00185049704	protein coding gene	Chr17:22242837-22245557 (+)
FVB/NJ	ENSMUSG00205050703	protein coding gene	Chr17:20494418-20497135 (+)
JF1/MsJ	ENSUMUG00000056965	protein coding gene	Chr17:21689161-21691879 (+)
LP/J	ENSMUSG00230054475	protein coding gene	Chr17:23640344-23643064 (+)
NOD/ShiLtJ	ENSMUSG00190048430	protein coding gene	Chr17:20131586-20134306 (+)
NZO/HlLtJ	ENSMUSG00225050089	protein coding gene	Chr17:25561975-25564695 (+)
PWK/PhJ	ENSLUMG00010017347	protein coding gene	Chr17:19598297-19601015 (+)
SPRET/EiJ	ENSMSPG00010045257	protein coding gene	Chr17:20934311-20937037 (+)
WSB/EiJ	ENSIUOG00005048856	protein coding gene	Chr17:20880441-20883159 (+)

Human Ortholog

PGP, phosphoglycolate phosphatase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PGP, phosphoglycolate phosphatase
Synonyms

AUM, G3PP, PGPase
Links

HGNC:8909

NCBI Gene ID: 283871

UniProt: A6NDG6
Chr Location

16p13.3; chr16:2211593-2214840 (-) GRCh38

MGI Vertebrate Homology

Pgp stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PGP
Protein SuperFamily

PGP-type_phosphatase
Gene Tree

Pgp

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Phenotype Summary

17 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Endonuclease-mediated

3
Gene trapped

16
Targeted

2
Find Mice (IMSR)

6 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are embryonic lethal and show embryonic growth retardation, delayed embryo turning, abnormal somitogenesis, hemorrhages, reduced blood vessel density in the placental labyrinth, and cell proliferation defects under normoxic conditions.

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All GO Annotations

41
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

103
cDNA Data

9
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pgp

ZFIN pgp

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All Sequences

39
RefSeq

2
UniProt

3
CCDS

CCDS28482.1

Ensembl

ENSMUSG00000043445 (Evidence)
NCBI Gene

67078

			Length	Strain/Species	Flank
genomic	67078	NCBI Gene Model \| MGI Sequence Detail	2685	C57BL/6J	± kb
transcript	NM_025954	RefSeq \| MGI Sequence Detail	2593	C57BL/6
polypeptide	Q8CHP8	UniProt \| EBI \| MGI Sequence Detail	321	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000012619 glycerol-3-phosphate phosphatase

(term hierarchy)
PDB

4BKM, 7PO7, 7POE
EC

3.1.3.18, 3.1.3.21, 3.1.3.48
InterPro Domains

IPR006349 2-phosphoglycolate phosphatase, eukaryotic

IPR036412 HAD-like superfamily

IPR023214 HAD superfamily

IPR006357 HAD-superfamily hydrolase, subfamily IIA
GlyGen

Q8CHP8 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 11

cDNA 10

Primer pair 1

Antibodies 1

Microarray probesets 5

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MGI:2146880

Summaries

All 43

Developmental Gene Expression 3

Gene Ontology 12

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:386735 Brenner M, et al., Metabolic rewiring driven by phosphoglycolate phosphatase deletion inhibits ferroptosis. Sci Adv. 2026 May 29;12(22):eaeb2368

TSS for Pgp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143033	Chr17:24689146-24689160 (+)	-247 bp
Tssr143034	Chr17:24689367-24689455 (+)	11 bp
Tssr143035	Chr17:24689460-24689477 (+)	69 bp
Tssr143036	Chr17:24689795-24689809 (+)	402 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24