Rps6ka6 MGI Mouse Gene Detail - MGI:1914321 - ribosomal protein S6 kinase A6

Symbol

Rps6ka6
Name

ribosomal protein S6 kinase A6
Synonyms

2610524K04Rik, RSK4

Feature Type

protein coding gene
IDs

MGI:1914321
NCBI Gene: 67071
Alliance

genome feature page
Transcription Start Sites

12 TSS

Sequence Map

ChrX:110297889-110447656 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 48.20 cM
Mapping Data

2 experiments

SNPs within 2kb

2320 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914321	protein coding gene	ChrX:110297534-110447794 (-)
129S1/SvImJ	ENSMUSG00200024092	protein coding gene	ChrX:92113923-92263688 (-)
A/J	ENSMUSG00195025939	protein coding gene	ChrX:95838854-95984684 (-)
AKR/J	ENSMUSG00220034106	protein coding gene	ChrX:90068256-90218034 (-)
BALB/cJ	ENSMUSG00180025344	protein coding gene	ChrX:92507151-92652956 (-)
C3H/HeJ	ENSMUSG00175026979	protein coding gene	ChrX:96112447-96258252 (-)
C57BL/6NJ	ENSMUSG00215012110	protein coding gene	ChrX:92736323-92886090 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033350	protein coding gene	ChrX:104793326-104940481 (-)
CAST/EiJ	ENSTCUG00005020394	protein coding gene	ChrX:93433005-93578175 (-)
CBA/J	ENSMUSG00210022196	protein coding gene	ChrX:92979454-93125267 (-)
DBA/2J	ENSMUSG00185028865	protein coding gene	ChrX:105443029-105592811 (-)
FVB/NJ	ENSMUSG00205019485	protein coding gene	ChrX:92057648-92203454 (-)
JF1/MsJ	ENSUMUG00000014336	protein coding gene	ChrX:126067683-126212961 (-)
LP/J	ENSMUSG00230005119	protein coding gene	ChrX:112080410-112230172 (-)
NOD/ShiLtJ	ENSMUSG00190013005	protein coding gene	ChrX:92186134-92335897 (-)
NZO/HlLtJ	ENSMUSG00225039680	protein coding gene	ChrX:117230744-117375939 (-)
PWK/PhJ	ENSLUMG00010036200	protein coding gene	ChrX:91340546-91486050 (-)
SPRET/EiJ	ENSMSPG00010021199	protein coding gene	ChrX:95664222-95810276 (-)
WSB/EiJ	ENSIUOG00005014919	protein coding gene	ChrX:92543761-92693486 (-)

Human Ortholog

RPS6KA6, ribosomal protein S6 kinase A6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RPS6KA6, ribosomal protein S6 kinase A6
Synonyms

p90RSK6, PP90RSK4, RSK-4, RSK4, S6K-alpha-6
Links

HGNC:10435

NCBI Gene ID: 27330

UniProt: Q9UK32
Chr Location

Xq21.1; chrX:84058346-84206356 (-) GRCh38

MGI Vertebrate Homology

Rps6ka6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RPS6KA6
Protein SuperFamily

Ribsml_S6_kin_2
Gene Tree

Rps6ka6

less

Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
23 images
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

4
Gene trapped

9
Targeted

2
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male chimeras hemizygous for a gene trapped allele exhibit a possible gastrulation defect, primitive streak and node defects, failure of chorioallantoic fusion, impaired embryo turning, posterior truncation, abnormal heart development, and microcephaly.

less

All GO Annotations

25
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

758
Tissues

74
cDNA Data

110
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rps6ka6

less

All Sequences

85
RefSeq

20
UniProt

11
CCDS

CCDS30356.1

Ensembl

ENSMUSG00000025665 (Evidence)
NCBI Gene

67071

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025665	Ensembl Gene Model \| MGI Sequence Detail	149768	C57BL/6J	± kb
transcript	ENSMUST00000123951	Ensembl \| MGI Sequence Detail	4328	Not Applicable
polypeptide	ENSMUSP00000115975	Ensembl \| MGI Sequence Detail	860	Not Applicable

less

UniProt

11 Sequences
Protein Ontology

PR:000014287 ribosomal protein S6 kinase alpha-6

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR000961 AGC-kinase, C-terminal

IPR017441 Protein kinase, ATP binding site

IPR017892 Protein kinase, C-terminal

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR016239 Ribosomal protein S6 kinase II

IPR041906 Ribosomal S6 kinase, N-terminal catalytic domain

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

Q7TPS0 2 sites, 2 N-linked glycans (2 sites)

less

All nucleic 113

cDNA 111

Primer pair 2

Microarray probesets 5

Summaries

All 46

Developmental Gene Expression 8

Gene Ontology 9

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:349696 Lekkos K, et al., Validation of positional candidates Rps6ka6 and Pou3f4 for a locus associated with skeletal muscle mass variability. G3 (Bethesda). 2024 May 7;14(5)

TSS for Rps6ka6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr164077	ChrX:110447654-110447661 (-)	-2 bp
Tssr164076	ChrX:110446082-110446085 (-)	1,572 bp
Tssr164075	ChrX:110446022-110446038 (-)	1,626 bp
Tssr164074	ChrX:110445998-110446014 (-)	1,650 bp
Tssr164073	ChrX:110440860-110440873 (-)	6,789 bp
Tssr164072	ChrX:110373175-110373217 (-)	74,460 bp
Tssr164071	ChrX:110373151-110373170 (-)	74,495 bp
Tssr164070	ChrX:110372846-110372870 (-)	74,798 bp
Tssr164069	ChrX:110372800-110372836 (-)	74,838 bp
Tssr164068	ChrX:110372760-110372778 (-)	74,887 bp
Tssr164067	ChrX:110372733-110372745 (-)	74,917 bp
Tssr164066	ChrX:110360359-110360370 (-)	87,291 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24