Lap3 Gene Detail

Summary

• Symbol
  Lap3
• Name
  leucine aminopeptidase 3
• Synonyms
  LAP, Pep7, Pep-7, Pep-S, peptidase S

• Feature Type
  protein coding gene
• IDs
  MGI:1914238
  NCBI Gene: 66988
• Alliance
  gene page
• Transcription Start Sites
  5 TSS

Location &
Maps

• Sequence Map
  Chr5:45650716-45670033 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 5, 24.98 cM
• Mapping Data
  11 experiments

Strain
Comparison

• SNPs within 2kb
  337 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914238	protein coding gene	Chr5:45650716-45670033 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029533	protein coding gene	Chr5:44197181-44218340 (+)
A/J	MGP_AJ_G0029501	protein coding gene	Chr5:42662592-42681954 (+)
AKR/J	MGP_AKRJ_G0029449	protein coding gene	Chr5:44154246-44173605 (+)
BALB/cJ	MGP_BALBcJ_G0029510	protein coding gene	Chr5:43146208-43165491 (+)
C3H/HeJ	MGP_C3HHeJ_G0029233	protein coding gene	Chr5:44159181-44178519 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029964	protein coding gene	Chr5:46289330-46308608 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027203	protein coding gene	Chr5:39832778-39851739 (+)
CAST/EiJ	MGP_CASTEiJ_G0028641	protein coding gene	Chr5:43304053-43323341 (+)
CBA/J	MGP_CBAJ_G0029202	protein coding gene	Chr5:47555718-47579687 (+)
DBA/2J	MGP_DBA2J_G0029348	protein coding gene	Chr5:42749652-42768979 (+)
FVB/NJ	MGP_FVBNJ_G0029308	protein coding gene	Chr5:42178565-42198083 (+)
LP/J	MGP_LPJ_G0029433	protein coding gene	Chr5:44682921-44703827 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029336	protein coding gene	Chr5:48301410-48320740 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029997	protein coding gene	Chr5:43671605-43691961 (+)
PWK/PhJ	MGP_PWKPhJ_G0028365	protein coding gene	Chr5:41875890-41895239 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028199	protein coding gene	Chr5:43115702-43138178 (+)
WSB/EiJ	MGP_WSBEiJ_G0028722	protein coding gene	Chr5:43735612-43754874 (+)

Homology

• Human Ortholog
  LAP3, leucine aminopeptidase 3

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  LAP3, leucine aminopeptidase 3
  
• Synonyms
  HEL-S-106, LAP, LAPEP, PEPS
• Links
  HGNC:18449

  NCBI Gene ID: 51056

  neXtProt AC: NX_P28838

  UniProt: P28838

  
  
• Chr Location
  4p15.32; chr4:17577198-17607972 (+)  GRCh38

---

• MGI Vertebrate Homology
  Lap3 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: LAP3
• Gene Tree
  Lap3
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  28 phenotype references
  

• All Mutations and Alleles
  21
• Chemically induced (other)
  2
• Endonuclease-mediated
  4
• Gene trapped
  11
• Radiation induced
  2
• Spontaneous
  1
• Targeted
  1
• Genomic Mutations
  5 involving Lap3
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  36 strains or lines available

Mice homozygous for a knock-out allele are viable and developmentally normal with no detectable abnormalities in generating peptides presented by MHC class I under constitutive conditions or after stimulation with IFN.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  9
• GO References
  7

Expression

• Assay Results
  841
• Tissues
  100
• cDNA Data
  271
• Literature Summary
  4

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase lap3
  ZFIN lap3

Sequences &
Gene Models

• All Sequences
  56
• RefSeq
  2
• UniProt
  2
• CCDS
  CCDS19274.1

• Ensembl
  ENSMUSG00000039682 (Evidence)
• NCBI Gene
  66988

Representative Sequences			Length	Strain/Species
genomic	66988	NCBI Gene Model | MGI Sequence Detail	19318	C57BL/6J
transcript	NM_024434	RefSeq | MGI Sequence Detail	2267	ZRU/MplStud
polypeptide	Q9CPY7	UniProt | EBI | MGI Sequence Detail	519	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000009664 cytosol aminopeptidase
  (term hierarchy)
• EC
  3.4.11.1, 3.4.11.5, 3.4.13.23
• InterPro Domains
  IPR043472 Macro domain-like
  IPR023042 Peptidase M17, leucine aminopeptidase
  IPR011356 Peptidase M17, leucine aminopeptidase/peptidase B
  IPR000819 Peptidase M17, leucyl aminopeptidase, C-terminal
  IPR008283 Peptidase M17, leucyl aminopeptidase, N-terminal

Molecular
Reagents

• All nucleic 271

  cDNA 271

  
  

  Microarray probesets 3

Other
Accession IDs

MGD-MRK-13235, MGD-MRK-13240, MGI:2140751, MGI:97543

References

• Summaries
  All 69

  Developmental Gene Expression 4

  Diseases 1

  Gene Ontology 7

  Phenotypes 28
• Earliest
  J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
• Latest
  J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Lap3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr1476	Chr5:45650716-45650726 (+)	5 bp
Tssr46135	Chr5:45650727-45650779 (+)	37 bp
Tssr46136	Chr5:45650791-45650808 (+)	84 bp
Tssr46137	Chr5:45650823-45650840 (+)	116 bp
Tssr46138	Chr5:45669663-45669679 (+)	18,955 bp