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Plin5 Gene Detail
Summary
  • Symbol
    Plin5
  • Name
    perilipin 5
  • Synonyms
    2310076L09Rik, Lsdp5, MLDP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914218
    NCBI Gene: 66968
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:56418601-56424596 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 17, 29.16 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    196 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914218
protein coding gene Chr17:56418601-56424606 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023913
protein coding gene Chr17:57756244-57762239 (-)
A/J MGP_AJ_G0023872
protein coding gene Chr17:56201748-56207743 (-)
AKR/J MGP_AKRJ_G0023842
protein coding gene Chr17:56872671-56878666 (-)
BALB/cJ MGP_BALBcJ_G0023874
protein coding gene Chr17:56025039-56031036 (-)
C3H/HeJ MGP_C3HHeJ_G0023637
protein coding gene Chr17:57584394-57590389 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024318
protein coding gene Chr17:60041997-60047992 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021765
protein coding gene Chr17:52697264-52703527 (-)
CAST/EiJ MGP_CASTEiJ_G0023120
protein coding gene Chr17:57897339-57903349 (-)
CBA/J MGP_CBAJ_G0023614
protein coding gene Chr17:62340422-62346417 (-)
DBA/2J MGP_DBA2J_G0023742
protein coding gene Chr17:54917011-54923010 (-)
FVB/NJ MGP_FVBNJ_G0023708
protein coding gene Chr17:54437376-54443371 (-)
LP/J MGP_LPJ_G0023822
protein coding gene Chr17:58463507-58469502 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023735
protein coding gene Chr17:61893958-61899953 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024363
protein coding gene Chr17:57249201-57255196 (-)
PWK/PhJ MGP_PWKPhJ_G0022865
protein coding gene Chr17:54263423-54269415 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022677
protein coding gene Chr17:54017223-54023180 (-)
WSB/EiJ MGP_WSBEiJ_G0023184
protein coding gene Chr17:57863224-57869218 (-)



Homology
more
  • Human Ortholog
    PLIN5, perilipin 5
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLIN5, perilipin 5
  • Synonyms
    LSDA5, LSDP5, MLDP, OXPAT
  • Links
    NCBI Gene ID: 440503
    neXtProt AC: NX_Q00G26
    UniProt: Q00G26

  • Chr Location
    19p13.3; chr19:4522531-4535224 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 3 alleles in 3 genetic backgrounds
    1 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit excessive fatty acid oxidation, abnormal lipid levels in organs depending on fed or fasted state, increased oxygen consumption and activity in the dark phase, and decreased cardiac muscle contractility in aged mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000011305 Ensembl Gene Model | MGI Sequence Detail 5996 C57BL/6J ±  kb
    transcript ENSMUST00000019808 Ensembl | MGI Sequence Detail 1986 Not Applicable  
    polypeptide ENSMUSP00000019808 Ensembl | MGI Sequence Detail 463 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2146846, MGI:2147046
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 4
      Gene Ontology 13
      Phenotypes 23
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:340032 Paredes A, et al., gamma-Linolenic acid in maternal milk drives cardiac metabolic maturation. Nature. 2023 Jun;618(7964):365-373

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    06/12/2024
    MGI 6.13
    The Jackson Laboratory