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Neat1 Gene Detail
Summary
  • Symbol
    Neat1
  • Name
    nuclear paraspeckle assembly transcript 1 (non-protein coding)
  • Synonyms
    2310043N10Rik
  • Feature Type
    lncRNA gene
  • IDs
    MGI:1914211
    NCBI Gene: 66961
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:5874736-5895508 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 4.34 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    147 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914211
 lncRNA gene Chr19:5874736-5895898 (-)
129S1/SvImJ MGP_129S1SvImJ_G0005809
 lincRNA gene Chr19:2828340-2849098 (-)
A/J MGP_AJ_G0005799
 lincRNA gene Chr19:2666350-2687121 (-)
AKR/J MGP_AKRJ_G0005775
 lincRNA gene Chr19:2745997-2766770 (-)
BALB/cJ MGP_BALBcJ_G0005778
 lincRNA gene Chr19:2659060-2680827 (-)
C3H/HeJ MGP_C3HHeJ_G0005726
 lincRNA gene Chr19:2758936-2779698 (-)
C57BL/6NJ MGP_C57BL6NJ_G0005938
 lincRNA gene Chr19:2890604-2911354 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0005281
 lincRNA gene Chr19:2575324-2596913 (-)
CAST/EiJ MGP_CASTEiJ_G0005666
 lincRNA gene Chr19:2774982-2795683 (-)
CBA/J MGP_CBAJ_G0005712
 lincRNA gene Chr19:3027205-3047949 (-)
DBA/2J MGP_DBA2J_G0005731
 lincRNA gene Chr19:2661291-2682034 (-)
FVB/NJ MGP_FVBNJ_G0005758
 lincRNA gene Chr19:2662952-2683764 (-)
LP/J MGP_LPJ_G0005812
 lincRNA gene Chr19:2788520-2810649 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0005744
 lincRNA gene Chr19:2858992-2879771 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0005936
 lincRNA gene Chr19:2761212-2781970 (-)
PWK/PhJ MGP_PWKPhJ_G0005611
 lincRNA gene Chr19:2688192-2708698 (-)
SPRET/EiJ MGP_SPRETEiJ_G0005527
 lincRNA gene Chr19:2751303-2771965 (-)
WSB/EiJ MGP_WSBEiJ_G0005718
 lincRNA gene Chr19:2769789-2791522 (-)



Homology
more
  • Human Ortholog
    NEAT1, nuclear paraspeckle assembly transcript 1
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEAT1, nuclear paraspeckle assembly transcript 1
  • Synonyms
    LINC00084, NCRNA00084, TncRNA, TP53LC15, VINC
  • Links
    NCBI Gene ID: 283131

  • Chr Location
    11q13.1; chr11:65422774-65445540 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NEAT1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation lack paraspeckles in the nucleus and exhibit reduced pup survival associated with impaired mammary gland development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    917
  • Tissues
    38
  • cDNA Data
    13
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      55
    • RefSeq
      2
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66961 NCBI Gene Model | MGI Sequence Detail 20773 C57BL/6J ±  kb
    transcript NR_131212 RefSeq | MGI Sequence Detail 20771 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 13
      Primer pair 10
      Other 5

      Microarray probesets 1
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 9
      Gene Ontology 5
      Phenotypes 22
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:344632 Chen S, et al., LncRNA Neat1 targets NonO and miR-128-3p to promote antigen-specific Th17 cell responses and autoimmune inflammation. Cell Death Dis. 2023 Sep 16;14(9):610
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory