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Mcub Gene Detail
Summary
  • Symbol
    Mcub
  • Name
    mitochondrial calcium uniporter dominant negative beta subunit
  • Synonyms
    9030408N13Rik, Ccdc109b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914065
    NCBI Gene: 66815
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:129708609-129763850 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 59.56 cM, cytoband H1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1854 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914065
 protein coding gene Chr3:129708609-129763855 (-)
129S1/SvImJ ENSMUSG00200002531
 protein coding gene Chr3:126477946-126533350 (-)
A/J ENSMUSG00195008095
 protein coding gene Chr3:126596105-126651334 (-)
AKR/J ENSMUSG00220021926
 protein coding gene Chr3:125034174-125089603 (-)
BALB/cJ ENSMUSG00180003613
 protein coding gene Chr3:126524792-126580027 (-)
C3H/HeJ ENSMUSG00175012222
 protein coding gene Chr3:126091157-126146588 (-)
C57BL/6NJ ENSMUSG00215011716
 protein coding gene Chr3:126857904-126913145 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025631
 protein coding gene Chr3:123514815-123578067 (-)
CAST/EiJ ENSTCUG00005003504
 protein coding gene Chr3:127172695-127234195 (-)
CBA/J ENSMUSG00210003671
 protein coding gene Chr3:126699762-126754988 (-)
DBA/2J ENSMUSG00185025354
 protein coding gene Chr3:127312827-127368258 (-)
FVB/NJ ENSMUSG00205016963
 protein coding gene Chr3:125647415-125702836 (-)
JF1/MsJ ENSUMUG00000027028
 protein coding gene Chr3:126050879-126115364 (-)
LP/J ENSMUSG00230002872
 protein coding gene Chr3:129298258-129353658 (-)
NOD/ShiLtJ ENSMUSG00190001202
 protein coding gene Chr3:127711955-127767386 (-)
NZO/HlLtJ ENSMUSG00225003147
 protein coding gene Chr3:131747545-131802976 (-)
PWK/PhJ ENSLUMG00010015246
 protein coding gene Chr3:126074292-126130274 (-)
SPRET/EiJ ENSMSPG00010012389
 protein coding gene Chr3:127049624-127107228 (-)
WSB/EiJ ENSIUOG00005016919
 protein coding gene Chr3:126825325-126880274 (-)



Homology
more
  • Human Ortholog
    MCUB, mitochondrial calcium uniporter dominant negative subunit beta
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MCUB, mitochondrial calcium uniporter dominant negative subunit beta
  • Synonyms
    CCDC109B
  • Links
    NCBI Gene ID: 55013
    UniProt: Q9NWR8

  • Chr Location
    4q25; chr4:109560209-109688719 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    20
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66815 NCBI Gene Model | MGI Sequence Detail 55242 C57BL/6J ±  kb
    transcript NM_025779 RefSeq | MGI Sequence Detail 1191 C57BL/6  
    polypeptide Q810S1 UniProt | EBI | MGI Sequence Detail 345 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 20

      Microarray probesets 3
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 9
      Phenotypes 19
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:346444 Bround MJ, et al., MCU-independent Ca(2+) uptake mediates mitochondrial Ca(2+) overload and necrotic cell death in a mouse model of Duchenne muscular dystrophy. Sci Rep. 2024 Mar 21;14(1):6751
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory