Gskip MGI Mouse Gene Detail - MGI:1914037 - GSK3B interacting protein

Symbol

Gskip
Name

GSK3B interacting protein
Synonyms

4933433P14Rik

Feature Type

protein coding gene
IDs

MGI:1914037
NCBI Gene: 66787
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr12:105651611-105669317 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 55.92 cM
Mapping Data

1 experiment

SNPs within 2kb

70 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914037	protein coding gene	Chr12:105651088-105669317 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020094	protein coding gene	Chr12:107565667-107587019 (+)
A/J	MGP_AJ_G0020048	protein coding gene	Chr12:103551846-103574674 (+)
AKR/J	MGP_AKRJ_G0020024	protein coding gene	Chr12:106555544-106574795 (+)
BALB/cJ	MGP_BALBcJ_G0020034	protein coding gene	Chr12:103968751-103986180 (+)
C3H/HeJ	MGP_C3HHeJ_G0019836	protein coding gene	Chr12:106982742-107001858 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020479	protein coding gene	Chr12:110879521-110900513 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018091	protein coding gene	Chr12:100156464-100165261 (+)
CAST/EiJ	MGP_CASTEiJ_G0019378	protein coding gene	Chr12:101789007-101809506 (+)
CBA/J	MGP_CBAJ_G0019803	protein coding gene	Chr12:115270746-115303722 (+)
DBA/2J	MGP_DBA2J_G0019920	protein coding gene	Chr12:103076117-103093930 (+)
FVB/NJ	MGP_FVBNJ_G0019905	protein coding gene	Chr12:101862414-101879842 (+)
LP/J	MGP_LPJ_G0019995	protein coding gene	Chr12:107463762-107482337 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019943	protein coding gene	Chr12:118678504-118699473 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020508	protein coding gene	Chr12:105943726-105962131 (+)
PWK/PhJ	MGP_PWKPhJ_G0019137	protein coding gene	Chr12:97666545-97684191 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018941	protein coding gene	Chr12:100167056-100185249 (+)
WSB/EiJ	MGP_WSBEiJ_G0019435	protein coding gene	Chr12:106898443-106915475 (+)

Human Ortholog

GSKIP, GSK3B interacting protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GSKIP, GSK3B interacting protein
Synonyms

C14orf129, HSPC210
Links

HGNC:20343

NCBI Gene ID: 51527

neXtProt AC: NX_Q9P0R6

UniProt: Q9P0R6
Chr Location

14q32.2; chr14:96363452-96387290 (+) GRCh38

MGI Vertebrate Homology

Gskip stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GSKIP
Gene Tree

Gskip

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Phenotype Summary

14 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

13
Targeted

3
Genomic Mutations

1 involving Gskip
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit partial lethality between E16.5 and E1.5, complete lethality at birth, cyanosis, primary atelectasis resulting in respiratory failure and cleft secondary palate due to delayed ossification in the upper jaw.

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All GO Annotations

24
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

820
Tissues

24
cDNA Data

13
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gskip

ZFIN gskip

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All Sequences

47
RefSeq

2
UniProt

4
CCDS

CCDS49161.1

Ensembl

ENSMUSG00000044715 (Evidence)
NCBI Gene

66787

			Length	Strain/Species	Flank
genomic	66787	NCBI Gene Model \| MGI Sequence Detail	17707	C57BL/6J	± kb
transcript	NM_178613	RefSeq \| MGI Sequence Detail	2787	C57BL/6
polypeptide	Q8BGR8	UniProt \| EBI \| MGI Sequence Detail	139	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000008289 GSK3B-interacting protein

(term hierarchy)
InterPro Domains

IPR037395 GSK3B-interacting protein

IPR007967 GSKIP domain

IPR023231 GSKIP domain superfamily

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All nucleic 15

cDNA 14

Primer pair 1

Microarray probesets 7

Summaries

All 31

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:320198 Sakai SS, et al., Loss of Atg2b and Gskip Impairs the Maintenance of the Hematopoietic Stem Cell Pool Size. Mol Cell Biol. 2022 Jan 20;42(1):e0002421

TSS for Gskip:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114912	Chr12:105650382-105650408 (+)	-1,216 bp
Tssr114913	Chr12:105651609-105651622 (+)	5 bp
Tssr114914	Chr12:105651643-105651689 (+)	55 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23