Zfp474 MGI Mouse Gene Detail - MGI:1914008

Symbol

Zfp474
Name

zinc finger protein 474
Synonyms

4933409D10Rik

Feature Type

protein coding gene
IDs

MGI:1914008
NCBI Gene: 66758
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr18:52748987-52772902 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 28.24 cM, cytoband D1
Mapping Data

2 experiments

SNPs within 2kb

309 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914008	protein coding gene	Chr18:52748979-52772904 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024429	protein coding gene	Chr18:51739404-51763274 (+)
A/J	MGP_AJ_G0024395	protein coding gene	Chr18:49749158-49772902 (+)
AKR/J	MGP_AKRJ_G0024365	protein coding gene	Chr18:51137802-51164033 (+)
BALB/cJ	MGP_BALBcJ_G0024395	protein coding gene	Chr18:49934768-49958507 (+)
C3H/HeJ	MGP_C3HHeJ_G0024162	protein coding gene	Chr18:51275225-51299131 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024841	protein coding gene	Chr18:53487457-53514342 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022273	protein coding gene	Chr18:49540790-49564886 (+)
CAST/EiJ	MGP_CASTEiJ_G0023636	protein coding gene	Chr18:51232752-51261007 (+)
CBA/J	MGP_CBAJ_G0024132	protein coding gene	Chr18:55060626-55084369 (+)
DBA/2J	MGP_DBA2J_G0024262	protein coding gene	Chr18:49457582-49481522 (+)
FVB/NJ	MGP_FVBNJ_G0024229	protein coding gene	Chr18:48882630-48907551 (+)
LP/J	MGP_LPJ_G0024347	protein coding gene	Chr18:51771437-51796172 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024259	protein coding gene	Chr18:56823027-56846941 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024888	protein coding gene	Chr18:51149847-51173756 (+)
PWK/PhJ	MGP_PWKPhJ_G0023380	protein coding gene	Chr18:49454719-49478790 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023186	protein coding gene	Chr18:51330965-51357436 (+)
WSB/EiJ	MGP_WSBEiJ_G0023699	protein coding gene	Chr18:51069391-51094691 (+)

Human Ortholog

ZNF474, zinc finger protein 474

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZNF474, zinc finger protein 474
Links

HGNC:23245

NCBI Gene ID: 133923

neXtProt AC: NX_Q6S9Z5

UniProt: Q6S9Z5
Chr Location

5q23.2; chr5:122129546-122182658 (+) GRCh38

Alliance of Genome Resources

Zfp474 stringent orthology
1 human;1 mouse;2 rat
HCOP

vertebrate homology predictions: ZNF474
Gene Tree

Zfp474

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Spontaneous

1
Targeted

2
Genomic Mutations

1 involving Zfp474
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

1
GO References

1

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

721
Tissues

8
cDNA Data

11
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Zfp474 interacts with 134 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

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All Sequences

48
RefSeq

18
UniProt

1
CCDS

CCDS29248.1

Ensembl

ENSMUSG00000046886 (Evidence)
NCBI Gene

66758

			Length	Strain/Species	Flank
genomic	ENSMUSG00000046886	Ensembl Gene Model \| MGI Sequence Detail	23916	C57BL/6J	± kb
transcript	ENSMUST00000209270	Ensembl \| MGI Sequence Detail	2113	Not Applicable
polypeptide	ENSMUSP00000147873	Ensembl \| MGI Sequence Detail	347	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000017918 zinc finger protein 474

(term hierarchy)
InterPro Domains

IPR026319 Zinc finger C2HC domain-containing protein

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All nucleic 12

cDNA 11

Primer pair 1

Microarray probesets 2

Summaries

All 24

Developmental Gene Expression 2

Gene Ontology 1

Phenotypes 5
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:327181 Lewis MA, et al., Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme. BMC Biol. 2022 Mar 17;20(1):67

TSS for Zfp474:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr151055	Chr18:52748980-52749068 (+)	37 bp
Tssr151056	Chr18:52749096-52749105 (+)	114 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/12/2023 MGI 6.22