Ccer1 MGI Mouse Gene Detail - MGI:1913966 - coiled-coil glutamate-rich protein 1

Symbol

Ccer1
Name

coiled-coil glutamate-rich protein 1
Synonyms

4921510H08Rik

Feature Type

protein coding gene
IDs

MGI:1913966
NCBI Gene: 66716
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr10:97528921-97530785 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 50.38 cM
Mapping Data

2 experiments

SNPs within 2kb

129 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913966	protein coding gene	Chr10:97528921-97530788 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017680	protein coding gene	Chr10:99440029-99441896 (+)
A/J	MGP_AJ_G0017659	protein coding gene	Chr10:95862897-95864764 (+)
AKR/J	MGP_AKRJ_G0017619	protein coding gene	Chr10:98584698-98586565 (+)
BALB/cJ	MGP_BALBcJ_G0017623	protein coding gene	Chr10:96158140-96160007 (+)
C3H/HeJ	MGP_C3HHeJ_G0017446	protein coding gene	Chr10:98619833-98621700 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018079	protein coding gene	Chr10:102874251-102876118 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015761	protein coding gene	Chr10:91364009-91365863 (+)
CAST/EiJ	MGP_CASTEiJ_G0017009	protein coding gene	Chr10:98685511-98687379 (+)
CBA/J	MGP_CBAJ_G0017415	protein coding gene	Chr10:106910564-106912431 (+)
DBA/2J	MGP_DBA2J_G0017521	protein coding gene	Chr10:94928569-94930436 (+)
FVB/NJ	MGP_FVBNJ_G0017514	protein coding gene	Chr10:94187848-94189715 (+)
LP/J	MGP_LPJ_G0017595	protein coding gene	Chr10:100032038-100033905 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017544	protein coding gene	Chr10:108087861-108089728 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018117	protein coding gene	Chr10:98518948-98520815 (+)
PWK/PhJ	MGP_PWKPhJ_G0016791	protein coding gene	Chr10:95086974-95088881 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016580	protein coding gene	Chr10:97395396-97397260 (+)
WSB/EiJ	MGP_WSBEiJ_G0017069	protein coding gene	Chr10:98529781-98531651 (+)

Human Ortholog

CCER1, coiled-coil glutamate rich protein 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCER1, coiled-coil glutamate rich protein 1
Synonyms

C12orf12
Links

HGNC:28373

NCBI Gene ID: 196477

UniProt: Q8TC90
Chr Location

12q21.33; chr12:90905622-90955176 (-) GRCh38

MGI Vertebrate Homology

Ccer1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CCER1
Gene Tree

Ccer1

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Phenotype Summary

16 phenotypes from 3 alleles in 3 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

1
Genomic Mutations

1 involving Ccer1
Incidental Mutations

APF
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mutation of this gene results in abnormal sperm head morphology, defective sperm chromatin compaction, reduced sperm count and motility, and male infertility.

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All GO Annotations

7
GO References

3

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

805
Tissues

11
cDNA Data

12
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

32
RefSeq

2
UniProt

1
CCDS

CCDS24144.1

Ensembl

ENSMUSG00000047025 (Evidence)
NCBI Gene

66716

			Length	Strain/Species	Flank
genomic	ENSMUSG00000047025	Ensembl Gene Model \| MGI Sequence Detail	1865	C57BL/6J	± kb
transcript	ENSMUST00000060703	Ensembl \| MGI Sequence Detail	1865	Not Applicable
polypeptide	ENSMUSP00000050554	Ensembl \| MGI Sequence Detail	403	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000031767 coiled-coil domain-containing glutamate-rich protein 1

(term hierarchy)
InterPro Domains

IPR027889 Coiled-coil domain-containing glutamate-rich protein family 1

IPR052696 Coiled-coil domain-containing protein
GlyGen

Q9CQL2 1 site

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All nucleic 12

cDNA 12

Microarray probesets 3

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MGI:2143788

Summaries

All 28

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 7
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:344358 Qin D, et al., Phase-separated CCER1 coordinates the histone-to-protamine transition and male fertility. Nat Commun. 2023 Dec 11;14(1):8209

TSS for Ccer1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr95502	Chr10:97528882-97528891 (+)	-34 bp
Tssr95503	Chr10:97528915-97528923 (+)	-2 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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