About   Help   FAQ
Spcs2 Gene Detail
Summary
  • Symbol
    Spcs2
  • Name
    signal peptidase complex subunit 2 homolog (S. cerevisiae)
  • Synonyms
    5730406I15Rik, MGC:60452, mKIAA0102
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913874
    NCBI Gene: 66624
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:99486775-99512576 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 54.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    159 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913874
 protein coding gene Chr7:99486775-99512669 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032558
 protein coding gene Chr7:102672054-102695124 (-)
A/J MGP_AJ_G0032532
 protein coding gene Chr7:100105733-100135770 (-)
AKR/J MGP_AKRJ_G0032468
 protein coding gene Chr7:102497639-102519720 (-)
BALB/cJ MGP_BALBcJ_G0032543
 protein coding gene Chr7:99782145-99803806 (-)
C3H/HeJ MGP_C3HHeJ_G0032258
 protein coding gene Chr7:102853425-102874562 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033041
 protein coding gene Chr7:106590364-106612847 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030035
 protein coding gene Chr7:102516100-102534883 (-)
CAST/EiJ MGP_CASTEiJ_G0031585
 protein coding gene Chr7:94378418-94402544 (-)
CBA/J MGP_CBAJ_G0032225
 protein coding gene Chr7:110263396-110292169 (-)
DBA/2J MGP_DBA2J_G0032376
 protein coding gene Chr7:98437523-98458368 (-)
FVB/NJ MGP_FVBNJ_G0032333
 protein coding gene Chr7:98234559-98255622 (-)
LP/J MGP_LPJ_G0032466
 protein coding gene Chr7:104030049-104052250 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032366
 protein coding gene Chr7:111688396-111711938 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033063
 protein coding gene Chr7:101757229-101779873 (-)
PWK/PhJ MGP_PWKPhJ_G0031303
 protein coding gene Chr7:91534487-91555679 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031146
 protein coding gene Chr7:89062212-89084234 (-)
WSB/EiJ MGP_WSBEiJ_G0031702
 protein coding gene Chr7:102438903-102461609 (-)



Homology
more
  • Human Ortholog
    SPCS2, signal peptidase complex subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPCS2, signal peptidase complex subunit 2
  • Links
    NCBI Gene ID: 9789
    neXtProt AC: NX_Q15005
    UniProt: Q15005

  • Chr Location
    11q13.4; chr11:74949261-74979033 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotype references
  • All Mutations and Alleles
    23
  • Chemically induced (other)
    1
  • Gene trapped
    18
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Spcs2
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    19 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    199
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 66624 NCBI Gene Model | MGI Sequence Detail 25802 C57BL/6J ±  kb
transcript NM_001418739 RefSeq | MGI Sequence Detail 2838 C57BL/6  
polypeptide Q9CYN2 UniProt | EBI | MGI Sequence Detail 226 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 199
    cDNA 199

    Microarray probesets 3
Other
Accession IDs
less
MGI:2141817
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 15
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory