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Snrnp40 Gene Detail
Summary
  • Symbol
    Snrnp40
  • Name
    small nuclear ribonucleoprotein 40 (U5)
  • Synonyms
    0610009C03Rik, Wdr57
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913835
    NCBI Gene: 66585
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:130253925-130283819 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 4, 63.43 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    345 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913835
protein coding gene Chr4:130253925-130283826 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028851
protein coding gene Chr4:132366081-132404094 (+)
A/J MGP_AJ_G0028810
protein coding gene Chr4:127053851-127084806 (+)
AKR/J MGP_AKRJ_G0028763
protein coding gene Chr4:130616998-130646868 (+)
BALB/cJ MGP_BALBcJ_G0028833
protein coding gene Chr4:127666639-127696539 (+)
C3H/HeJ MGP_C3HHeJ_G0028547
protein coding gene Chr4:130673216-130706371 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029275
protein coding gene Chr4:137317613-137357267 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026547
protein coding gene Chr4:120168630-120197280 (+)
CAST/EiJ MGP_CASTEiJ_G0027980
protein coding gene Chr4:128888013-128916522 (+)
CBA/J MGP_CBAJ_G0028513
protein coding gene Chr4:140820514-140854205 (+)
DBA/2J MGP_DBA2J_G0028662
protein coding gene Chr4:127488370-127518146 (+)
FVB/NJ MGP_FVBNJ_G0028629
protein coding gene Chr4:126280809-126313220 (+)
LP/J MGP_LPJ_G0028763
protein coding gene Chr4:132693850-132723876 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028655
protein coding gene Chr4:145517196-145550893 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029313
protein coding gene Chr4:130989143-131018025 (+)
PWK/PhJ MGP_PWKPhJ_G0027701
protein coding gene Chr4:124116860-124146589 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027527
protein coding gene Chr4:126854122-126884002 (+)
WSB/EiJ MGP_WSBEiJ_G0028060
protein coding gene Chr4:131134574-131165941 (+)



Homology
more
  • Human Ortholog
    SNRNP40, small nuclear ribonucleoprotein U5 subunit 40
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SNRNP40, small nuclear ribonucleoprotein U5 subunit 40
  • Synonyms
    40K, HPRP8BP, PRP8BP, PRPF8BP, SPF38, WDR57
  • Links
    NCBI Gene ID: 9410
    neXtProt AC: NX_Q96DI7
    UniProt: Q96DI7

  • Chr Location
    1p35.2; chr1:31259568-31296788 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 4 alleles in 6 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit lethality before weaning. Mice homozygous for a hypomorph exhibit reduced body weight, belly spotting, and immunodeficiency.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000074088 Ensembl Gene Model | MGI Sequence Detail 29895 C57BL/6J ±  kb
    transcript ENSMUST00000105994 Ensembl | MGI Sequence Detail 1584 Not Applicable  
    polypeptide ENSMUSP00000101616 Ensembl | MGI Sequence Detail 358 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 3
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory