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Polr2l Gene Detail
Summary
  • Symbol
    Polr2l
  • Name
    polymerase (RNA) II (DNA directed) polypeptide L
  • Synonyms
    2510029B14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913741
    NCBI Gene: 66491
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:141051773-141055045 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 86.83 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    45 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913741
 protein coding gene Chr7:141051773-141055066 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033235
 protein coding gene Chr7:146664769-146668129 (-)
A/J MGP_AJ_G0026408
 protein coding gene Chr2:124676780-124678177 (-)
AKR/J MGP_AKRJ_G0033149
 protein coding gene Chr7:146420955-146424155 (-)
BALB/cJ MGP_BALBcJ_G0026418
 protein coding gene Chr2:124939751-124941148 (-)
C3H/HeJ MGP_C3HHeJ_G0032932
 protein coding gene Chr7:146156269-146159479 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033729
 protein coding gene Chr7:152015930-152019262 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030702
 protein coding gene Chr7:143677136-143680226 (-)
CAST/EiJ MGP_CASTEiJ_G0032262
 protein coding gene Chr7:138470215-138473318 (-)
CBA/J MGP_CBAJ_G0032904
 protein coding gene Chr7:157175736-157178931 (-)
DBA/2J MGP_DBA2J_G0033056
 protein coding gene Chr7:140414308-140417591 (-)
FVB/NJ MGP_FVBNJ_G0033009
 protein coding gene Chr7:140329221-140332585 (-)
LP/J MGP_LPJ_G0033151
 protein coding gene Chr7:148157264-148160625 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033042
 protein coding gene Chr7:157810107-157813473 (-)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0031966
 protein coding gene Chr7:133699410-133702506 (-)
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    POLR2L, RNA polymerase II, I and III subunit L
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POLR2L, RNA polymerase II, I and III subunit L
  • Synonyms
    hRPB7.6, RBP10, RPABC5, RPB10, RPB10beta, RPB7.6
  • Links
    NCBI Gene ID: 5441
    neXtProt AC: NX_P62875
    UniProt: P62875

  • Chr Location
    11p15.5; chr11:837356-842529 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    21
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    939
  • Tissues
    112
  • cDNA Data
    73
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038489 Ensembl Gene Model | MGI Sequence Detail 3273 C57BL/6J ±  kb
transcript ENSMUST00000043870 Ensembl | MGI Sequence Detail 1650 Not Applicable  
polypeptide ENSMUSP00000043204 Ensembl | MGI Sequence Detail 67 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000012999 DNA-directed RNA polymerases I, II, and III subunit RPABC5
    (term hierarchy)
  • InterPro Domains
    IPR000268 DNA-directed RNA polymerase subunit RPABC5/Rpb10
    IPR020789 RNA polymerases, subunit N, zinc binding site
    IPR023580 RNA polymerase subunit RPB10
Molecular
Reagents
less
  • All nucleic 74
    cDNA 73
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 32
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory