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Alkbh7 Gene Detail
Summary
  • Symbol
    Alkbh7
  • Name
    alkB homolog 7
  • Synonyms
    2310045B01Rik, 2510008E23Rik, Abh7, Spata11
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913650
    NCBI Gene: 66400
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:57304339-57306322 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 29.61 cM, cytoband E1.1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    143 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913650
 protein coding gene Chr17:57304339-57306340 (+)
129S1/SvImJ ENSMUSG00200016562
 protein coding gene Chr17:52579830-52581815 (+)
A/J ENSMUSG00195006523
 protein coding gene Chr17:53967755-53969738 (+)
AKR/J ENSMUSG00220012238
 protein coding gene Chr17:53017100-53019083 (+)
BALB/cJ ENSMUSG00180006119
 protein coding gene Chr17:53725419-53727402 (+)
C3H/HeJ ENSMUSG00175006723
 protein coding gene Chr17:53041387-53043370 (+)
C57BL/6NJ ENSMUSG00215005309
 protein coding gene Chr17:52655553-52657536 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021797
 protein coding gene Chr17:53598462-53600441 (+)
CAST/EiJ ENSTCUG00005019071
 protein coding gene Chr17:53772708-53774690 (+)
CBA/J ENSMUSG00210028373
 protein coding gene Chr17:52808447-52810429 (+)
DBA/2J ENSMUSG00185008052
 protein coding gene Chr17:55678294-55680277 (+)
FVB/NJ ENSMUSG00205007220
 protein coding gene Chr17:53355528-53357512 (+)
JF1/MsJ ENSUMUG00000033260
 protein coding gene Chr17:55365772-55367749 (+)
LP/J ENSMUSG00230026517
 protein coding gene Chr17:56657175-56659160 (+)
NOD/ShiLtJ ENSMUSG00190009474
 protein coding gene Chr17:52810731-52812716 (+)
NZO/HlLtJ ENSMUSG00225043090
 protein coding gene Chr17:58941469-58943452 (+)
PWK/PhJ ENSLUMG00010008457
 protein coding gene Chr17:52617122-52619099 (+)
SPRET/EiJ ENSMSPG00010004968
 protein coding gene Chr17:52938440-52940404 (+)
WSB/EiJ ENSIUOG00005022050
 protein coding gene Chr17:53716794-53718777 (+)



Homology
more
  • Human Ortholog
    ALKBH7, alkB homolog 7, RNA demethylase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALKBH7, alkB homolog 7, RNA demethylase
  • Synonyms
    ABH7, SPATA11, UNQ6002
  • Links
    NCBI Gene ID: 84266
    UniProt: Q9BT30

  • Chr Location
    19p13.3; chr19:6372763-6375250 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout affects lipid and carbohydrate metabolism which leads to obesity and increased sensitivity to diet-induced obesity. It also increases resistance to alkylation-induced cell death and mortality in males (and females for some tissues) and protects the heart from ischemia-reperfusion (IR) injury in males.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    599
  • Tissues
    1
  • cDNA Data
    39
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002661 Ensembl Gene Model | MGI Sequence Detail 1984 C57BL/6J ±  kb
    transcript ENSMUST00000002737 Ensembl | MGI Sequence Detail 917 Not Applicable  
    polypeptide ENSMUSP00000002737 Ensembl | MGI Sequence Detail 221 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000003954 RNA demethylase ALKBH7, mitochondrial
      (term hierarchy)
    • EC
      1.14.11.-
    • InterPro Domains
      IPR032870 Alpha-ketoglutarate-dependent dioxygenase alkB homologue 7-like
      IPR027450 Alpha-ketoglutarate-dependent dioxygenase AlkB-like
      IPR037151 Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 39
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1917538
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 1
      Gene Ontology 10
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory