Iscu MGI Mouse Gene Detail - MGI:1913633 - iron-sulfur cluster assembly enzyme

Symbol

Iscu
Name

iron-sulfur cluster assembly enzyme
Synonyms

2310020H20Rik, Nifun

Feature Type

protein coding gene
IDs

MGI:1913633
NCBI Gene: 66383
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr5:113910809-113916349 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 55.55 cM
Mapping Data

2 experiments

SNPs within 2kb

10 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913633	protein coding gene	Chr5:113910479-113916349 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029923	protein coding gene	Chr5:116450729-116456272 (+)
A/J	MGP_AJ_G0029888	protein coding gene	Chr5:111889666-111898953 (+)
AKR/J	MGP_AKRJ_G0029826	protein coding gene	Chr5:115438826-115445920 (+)
BALB/cJ	MGP_BALBcJ_G0029899	protein coding gene	Chr5:113262065-113267616 (+)
C3H/HeJ	MGP_C3HHeJ_G0029619	protein coding gene	Chr5:115929678-115936771 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030353	protein coding gene	Chr5:120971061-120976650 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027581	protein coding gene	Chr5:106719265-106724474 (+)
CAST/EiJ	MGP_CASTEiJ_G0029027	protein coding gene	Chr5:114852727-114858055 (+)
CBA/J	MGP_CBAJ_G0029586	protein coding gene	Chr5:125532302-125539163 (+)
DBA/2J	MGP_DBA2J_G0029736	protein coding gene	Chr5:111955006-111960765 (+)
FVB/NJ	MGP_FVBNJ_G0029693	protein coding gene	Chr5:110728157-110742898 (+)
LP/J	MGP_LPJ_G0029825	protein coding gene	Chr5:117020676-117028818 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029724	protein coding gene	Chr5:130037191-130044167 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030394	protein coding gene	Chr5:114890747-114897492 (+)
PWK/PhJ	MGP_PWKPhJ_G0028741	protein coding gene	Chr5:110580413-110585888 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028579	protein coding gene	Chr5:112420548-112425839 (+)
WSB/EiJ	MGP_WSBEiJ_G0029103	protein coding gene	Chr5:115451549-115460130 (+)

Human Ortholog

ISCU, iron-sulfur cluster assembly enzyme

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ISCU, iron-sulfur cluster assembly enzyme
Synonyms

2310020H20Rik, HML, hnifU, ISU2, NIFU, NIFUN
Links

HGNC:29882

NCBI Gene ID: 23479

neXtProt AC: NX_Q9H1K1

UniProt: Q9H1K1
Chr Location

12q23.3; chr12:108561463-108569384 (+) GRCh38

MGI Vertebrate Homology

Iscu stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ISCU
Gene Tree

Iscu

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Radiation induced

1
Targeted

1
Genomic Mutations

2 involving Iscu
Find Mice (IMSR)

7 strains or lines available

Homozygous null embryos die prior to implantation.

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All GO Annotations

33
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

11
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase iscu

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All Sequences

61
RefSeq

8
UniProt

6
CCDS

CCDS19553.1

Ensembl

ENSMUSG00000025825 (Evidence)
NCBI Gene

66383

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025825	Ensembl Gene Model \| MGI Sequence Detail	5541	C57BL/6J	± kb
transcript	ENSMUST00000112311	Ensembl \| MGI Sequence Detail	1395	Not Applicable
polypeptide	ENSMUSP00000107930	Ensembl \| MGI Sequence Detail	209	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000009113 iron-sulfur cluster assembly enzyme ISCU

(term hierarchy)
PDB

1WFZ
InterPro Domains

IPR011339 Iron-sulfur cluster assembly scaffold protein IscU

IPR002871 NIF system FeS cluster assembly, NifU, N-terminal

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All nucleic 11

cDNA 11

Microarray probesets 5

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MGI:2147429

Summaries

All 46

Developmental Gene Expression 1

Gene Ontology 10

Phenotypes 10
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:264015 Roy AR, et al., The transcriptional regulator CCCTC-binding factor limits oxidative stress in endothelial cells. J Biol Chem. 2018 Jun 1;293(22):8449-8461

TSS for Iscu:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48032	Chr5:113910847-113910888 (+)	59 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23