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Ttll9 Gene Detail
Summary
  • Symbol
    Ttll9
  • Name
    tubulin tyrosine ligase-like family, member 9
  • Synonyms
    1700016F23Rik, 4930509O20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913589
    NCBI Gene: 74711
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:152804405-152850402 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 75.41 cM, cytoband H2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1575 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913589
protein coding gene Chr2:152792966-152850402 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026683
protein coding gene Chr2:157565373-157617052 (+)
A/J MGP_AJ_G0026649
protein coding gene Chr2:151261828-151310267 (+)
AKR/J MGP_AKRJ_G0026619
protein coding gene Chr2:155685320-155733445 (+)
BALB/cJ MGP_BALBcJ_G0026658
protein coding gene Chr2:151572189-151620202 (+)
C3H/HeJ MGP_C3HHeJ_G0026401
protein coding gene Chr2:156053711-156102652 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027107
protein coding gene Chr2:162139353-162189507 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024478
protein coding gene Chr2:144853322-144898857 (+)
CAST/EiJ MGP_CASTEiJ_G0025862
protein coding gene Chr2:156315030-156364719 (+)
CBA/J MGP_CBAJ_G0026379
protein coding gene Chr2:168103530-168154450 (+)
DBA/2J MGP_DBA2J_G0026515
protein coding gene Chr2:150471382-150516956 (+)
FVB/NJ MGP_FVBNJ_G0026481
protein coding gene Chr2:148938803-148984866 (+)
LP/J MGP_LPJ_G0026619
protein coding gene Chr2:157714567-157764796 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026502
protein coding gene Chr2:172165899-172221133 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027163
protein coding gene Chr2:155578616-155629112 (+)
PWK/PhJ MGP_PWKPhJ_G0025596
protein coding gene Chr2:150001795-150053460 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025399
protein coding gene Chr2:154411965-154462403 (+)
WSB/EiJ MGP_WSBEiJ_G0025932
protein coding gene Chr2:156483070-156531075 (+)



Homology
more
  • Human Ortholog
    TTLL9, tubulin tyrosine ligase like 9
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TTLL9, tubulin tyrosine ligase like 9
  • Synonyms
    C20orf125
  • Links
    NCBI Gene ID: 164395
    neXtProt AC: NX_Q3SXZ7
    UniProt: Q3SXZ7

  • Chr Location
    20q11.21; chr20:31870634-31945000 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility associated with oligozoospermia, detached sperm flagella, abnormal sperm axonemes with loss of doublet 7 and reduced polyglutamylation of doublet 5, and asthenozoospermia with frequent stalls after anti-hook bending.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000074673 Ensembl Gene Model | MGI Sequence Detail 45998 C57BL/6J ±  kb
    transcript ENSMUST00000103155 Ensembl | MGI Sequence Detail 1552 Not Applicable  
    polypeptide ENSMUSP00000099444 Ensembl | MGI Sequence Detail 464 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1921961, MGI:2146611
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 7
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:259707 Ye B, et al., Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice. Nat Commun. 2018 Mar 28;9(1):1261

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    11/19/2024
    MGI 6.24
    The Jackson Laboratory