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Mplkip Gene Detail
Summary
  • Symbol
    Mplkip
  • Name
    M-phase specific PLK1 intereacting protein
  • Synonyms
    2810021B07Rik, C330007M08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913558
    NCBI Gene: 66308
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:17869998-17873697 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 6.05 cM, cytoband A3.1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    177 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913558
 protein coding gene Chr13:17869777-17874333 (+)
129S1/SvImJ ENSMUSG00200013668
 protein coding gene Chr13:15108763-15112676 (+)
A/J ENSMUSG00195035359
 protein coding gene Chr13:14212118-14216031 (+)
AKR/J ENSMUSG00220031604
 protein coding gene Chr13:14164683-14168597 (+)
BALB/cJ ENSMUSG00180035687
 protein coding gene Chr13:14566743-14570656 (+)
C3H/HeJ ENSMUSG00175031762
 protein coding gene Chr13:14668530-14672443 (+)
C57BL/6NJ ENSMUSG00215017968
 protein coding gene Chr13:14625960-14629873 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018245
 protein coding gene Chr13:13095140-13098830 (+)
CAST/EiJ ENSTCUG00005013417
 protein coding gene Chr13:14720634-14724553 (+)
CBA/J ENSMUSG00210029642
 protein coding gene Chr13:14528466-14532379 (+)
DBA/2J ENSMUSG00185012461
 protein coding gene Chr13:15223347-15227260 (+)
FVB/NJ ENSMUSG00205021936
 protein coding gene Chr13:14395616-14399529 (+)
JF1/MsJ ENSUMUG00000015014
 protein coding gene Chr13:14980417-14984331 (+)
LP/J ENSMUSG00230031288
 protein coding gene Chr13:24632234-24636147 (+)
NOD/ShiLtJ ENSMUSG00190020737
 protein coding gene Chr13:14499437-14503350 (+)
NZO/HlLtJ ENSMUSG00225032306
 protein coding gene Chr13:18388991-18392904 (+)
PWK/PhJ ENSLUMG00010025807
 protein coding gene Chr13:13949457-13953380 (+)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005031599
 protein coding gene Chr13:13834357-13838270 (+)



Homology
more
  • Human Ortholog
    MPLKIP, M-phase specific PLK1 interacting protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MPLKIP, M-phase specific PLK1 interacting protein
  • Synonyms
    ABHS, C7orf11, ORF20, TTD4
  • Links
    NCBI Gene ID: 136647
    UniProt: Q8TAP9

  • Chr Location
    7p14.1; chr7:40126027-40134622 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MPLKIP associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 3 alleles in 3 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout is partially prenatal lethal and leads to slow postnatal weight gain, smaller brains in males and fine motor control and/or motivational deficits.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    616
  • Tissues
    11
  • cDNA Data
    12
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66308 NCBI Gene Model | MGI Sequence Detail 3700 C57BL/6J ±  kb
    transcript NM_025479 RefSeq | MGI Sequence Detail 2679 C57BL/6  
    polypeptide Q9D011 UniProt | EBI | MGI Sequence Detail 178 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1924888
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 17
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory