Fam53c MGI Mouse Gene Detail - MGI:1913556 - family with sequence similarity 53, member C

Symbol

Fam53c
Name

family with sequence similarity 53, member C
Synonyms

2810012G03Rik

Feature Type

protein coding gene
IDs

MGI:1913556
NCBI Gene: 66306
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr18:34891959-34906813 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 18.72 cM
Mapping Data

2 experiments

SNPs within 2kb

49 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913556	protein coding gene	Chr18:34891885-34906813 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024250	protein coding gene	Chr18:32993399-33008239 (+)
A/J	MGP_AJ_G0024216	protein coding gene	Chr18:31873844-31888698 (+)
AKR/J	MGP_AKRJ_G0024184	protein coding gene	Chr18:32793850-32808579 (+)
BALB/cJ	MGP_BALBcJ_G0024216	protein coding gene	Chr18:31933421-31948171 (+)
C3H/HeJ	MGP_C3HHeJ_G0023983	protein coding gene	Chr18:32805819-32820664 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024658	protein coding gene	Chr18:34263414-34278324 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022098	protein coding gene	Chr18:32016610-32031142 (+)
CAST/EiJ	MGP_CASTEiJ_G0023458	protein coding gene	Chr18:32758951-32773658 (+)
CBA/J	MGP_CBAJ_G0023951	protein coding gene	Chr18:35191664-35206520 (+)
DBA/2J	MGP_DBA2J_G0024083	protein coding gene	Chr18:31530505-31545357 (+)
FVB/NJ	MGP_FVBNJ_G0024050	protein coding gene	Chr18:31214893-31229721 (+)
LP/J	MGP_LPJ_G0024165	protein coding gene	Chr18:33073580-33089534 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024078	protein coding gene	Chr18:36454401-36469246 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024706	protein coding gene	Chr18:32609459-32624301 (+)
PWK/PhJ	MGP_PWKPhJ_G0023202	protein coding gene	Chr18:31733189-31747965 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023010	protein coding gene	Chr18:32886736-32901634 (+)
WSB/EiJ	MGP_WSBEiJ_G0023521	protein coding gene	Chr18:32541980-32556820 (+)

Human Ortholog

FAM53C, family with sequence similarity 53 member C

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FAM53C, family with sequence similarity 53 member C
Synonyms

C5orf6
Links

HGNC:1336

NCBI Gene ID: 51307

neXtProt AC: NX_Q9NYF3

UniProt: Q9NYF3
Chr Location

5q31.2; chr5:138331935-138349729 (+) GRCh38

Alliance of Genome Resources

Fam53c stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FAM53C
Gene Tree

Fam53c

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

2
Gene trapped

5
Targeted

2
Incidental Mutations

CvDC
Find Mice (IMSR)

17 strains or lines available

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All GO Annotations

2
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

128

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fam53c

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Fam53c interacts with 326 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

61
RefSeq

10
UniProt

3
CCDS

CCDS29134.1

Ensembl

ENSMUSG00000034300 (Evidence)
NCBI Gene

66306

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034300	Ensembl Gene Model \| MGI Sequence Detail	14855	C57BL/6J	± kb
transcript	ENSMUST00000049281	Ensembl \| MGI Sequence Detail	4475	Not Applicable
polypeptide	ENSMUSP00000037034	Ensembl \| MGI Sequence Detail	393	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000031764 protein FAM53C

(term hierarchy)
InterPro Domains

IPR029356 Family of FAM53

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All nucleic 128

cDNA 128

Microarray probesets 3

Summaries

All 30

Gene Ontology 1

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

TSS for Fam53c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr150472	Chr18:34891906-34891932 (+)	-40 bp
Tssr150473	Chr18:34891943-34891950 (+)	-12 bp
Tssr150474	Chr18:34892153-34892165 (+)	200 bp
Tssr150476	Chr18:34895687-34895696 (+)	3,733 bp
Tssr150477	Chr18:34901331-34901340 (+)	9,377 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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