Gkn2 MGI Mouse Gene Detail - MGI:1913534

Symbol

Gkn2
Name

gastrokine 2
Synonyms

1810036H07Rik, Bricd1b

Feature Type

protein coding gene
IDs

MGI:1913534
NCBI Gene: 66284
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr6:87350347-87356476 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 37.96 cM, cytoband D2
Mapping Data

2 experiments

SNPs within 2kb

42 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913534	protein coding gene	Chr6:87350339-87356479 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030990	protein coding gene	Chr6:88725344-88731494 (+)
A/J	MGP_AJ_G0030956	protein coding gene	Chr6:85293510-85299665 (+)
AKR/J	MGP_AKRJ_G0030887	protein coding gene	Chr6:87763854-87769994 (+)
BALB/cJ	MGP_BALBcJ_G0030969	protein coding gene	Chr6:85295962-85302102 (+)
C3H/HeJ	MGP_C3HHeJ_G0030741	protein coding gene	Chr6:96709154-96715304 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031426	protein coding gene	Chr6:91110916-91117056 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028610	protein coding gene	Chr6:83475641-83483602 (+)
CAST/EiJ	MGP_CASTEiJ_G0030078	protein coding gene	Chr6:87835375-87841499 (+)
CBA/J	MGP_CBAJ_G0030653	protein coding gene	Chr6:94651031-94657181 (+)
DBA/2J	MGP_DBA2J_G0030809	protein coding gene	Chr6:84599242-84605392 (+)
FVB/NJ	MGP_FVBNJ_G0030762	protein coding gene	Chr6:83779903-83786053 (+)
LP/J	MGP_LPJ_G0030886	protein coding gene	Chr6:88736772-88742922 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030795	protein coding gene	Chr6:98766667-98772817 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031453	protein coding gene	Chr6:87606684-87612829 (+)
PWK/PhJ	MGP_PWKPhJ_G0029793	protein coding gene	Chr6:83562862-83568995 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029621	protein coding gene	Chr6:86423838-86430035 (+)
WSB/EiJ	MGP_WSBEiJ_G0030159	protein coding gene	Chr6:88064886-88071026 (+)

Human Ortholog

GKN2, gastrokine 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GKN2, gastrokine 2
Synonyms

BRICD1B, GDDR, PRO813, TFIZ1, VLTI465
Links

HGNC:24588

NCBI Gene ID: 200504

neXtProt AC: NX_Q86XP6

UniProt: Q86XP6
Chr Location

2p13.3; chr2:68945232-68952893 (-) GRCh38

Alliance of Genome Resources

Gkn2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: GKN2
Gene Tree

Gkn2

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Phenotype Summary

21 phenotypes from 1 allele in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

1
Spontaneous

1
Targeted

7
Genomic Mutations

1 involving Gkn2
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice have impaired basal gastric epithelial differentiation and show accelerated progression to atrophic gastritis and metaplasia, hyperactivated Th1 immunity, increased mucosal innate immunity and impaired myeloid-derived suppressor cell responses after H. pylori infection.

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All GO Annotations

6
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

748
Tissues

31
cDNA Data

18
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Gkn2 interacts with 42 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

32
RefSeq

2
UniProt

1
CCDS

CCDS39546.1

Ensembl

ENSMUSG00000030049 (Evidence)
NCBI Gene

66284

			Length	Strain/Species	Flank
genomic	66284	NCBI Gene Model \| MGI Sequence Detail	6130	C57BL/6J	± kb
transcript	NM_025467	RefSeq \| MGI Sequence Detail	777	C57BL/6
polypeptide	Q9CQS6	UniProt \| EBI \| MGI Sequence Detail	184	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008014 gastrokine-2

(term hierarchy)
InterPro Domains

IPR007084 BRICHOS domain

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All nucleic 19

cDNA 18

Primer pair 1

Microarray probesets 3

Summaries

All 45

Developmental Gene Expression 4

Gene Ontology 4

Phenotypes 20
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:322734 Steiner S, et al., De novo expression of gastrokines in pancreatic precursor lesions impede the development of pancreatic cancer. Oncogene. 2022 Mar;41(10):1507-1517

TSS for Gkn2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr57536	Chr6:87350339-87350352 (+)	-1 bp
Tssr57537	Chr6:87352732-87352750 (+)	2,394 bp
Tssr57538	Chr6:87352770-87352778 (+)	2,427 bp
Tssr57539	Chr6:87352790-87352804 (+)	2,450 bp
Tssr57540	Chr6:87355109-87355123 (+)	4,769 bp
Tssr57541	Chr6:87356267-87356274 (+)	5,924 bp
Tssr1924	Chr6:87356332-87356338 (+)	5,988 bp
Tssr57542	Chr6:87356345-87356356 (+)	6,004 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/19/2023 MGI 6.22