Tmem218 MGI Mouse Gene Detail - MGI:1913529

Symbol

Tmem218
Name

transmembrane protein 218
Synonyms

1810021J13Rik

Feature Type

protein coding gene
IDs

MGI:1913529
NCBI Gene: 66279
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr9:37119519-37134524 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 20.74 cM
Mapping Data

2 experiments

SNPs within 2kb

621 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913529	protein coding gene	Chr9:37119519-37135996 (+)
129S1/SvImJ	ENSMUSG00200037620	protein coding gene	Chr9:34105683-34123314 (+)
A/J	ENSMUSG00195047758	protein coding gene	Chr9:33892290-33909921 (+)
AKR/J	ENSMUSG00220042411	protein coding gene	Chr9:33969336-33986947 (+)
BALB/cJ	ENSMUSG00180042989	protein coding gene	Chr9:34020610-34038239 (+)
C3H/HeJ	ENSMUSG00175047826	protein coding gene	Chr9:34021636-34039269 (+)
C57BL/6NJ	ENSMUSG00215032307	protein coding gene	Chr9:34025369-34041839 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031977	protein coding gene	Chr9:33364090-33379635 (+)
CAST/EiJ	ENSTCUG00005041820	protein coding gene	Chr9:33985238-34002696 (+)
CBA/J	ENSMUSG00210041281	protein coding gene	Chr9:34018640-34036234 (+)
DBA/2J	ENSMUSG00185031236	protein coding gene	Chr9:34118748-34136361 (+)
FVB/NJ	ENSMUSG00205033566	protein coding gene	Chr9:34383893-34401548 (+)
JF1/MsJ	ENSUMUG00000028659	protein coding gene	Chr9:34222565-34240019 (+)
LP/J	ENSMUSG00230027710	protein coding gene	Chr9:34480460-34497905 (+)
NOD/ShiLtJ	ENSMUSG00190029999	protein coding gene	Chr9:34149833-34167471 (+)
NZO/HlLtJ	ENSMUSG00225019915	protein coding gene	Chr9:34448870-34466315 (+)
PWK/PhJ	ENSLUMG00010045427	protein coding gene	Chr9:34163327-34180826 (+)
SPRET/EiJ	ENSMSPG00010027713	protein coding gene	Chr9:34723446-34740812 (+)
WSB/EiJ	ENSIUOG00005040504	protein coding gene	Chr9:33643611-33661226 (+)

Human Ortholog

TMEM218, transmembrane protein 218

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM218, transmembrane protein 218
Synonyms

JBTS39
Links

HGNC:27344

NCBI Gene ID: 219854

UniProt: A2RU14
Chr Location

11q24.2; chr11:125094386-125111870 (-) GRCh38

MGI Vertebrate Homology

Tmem218 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMEM218
Gene Tree

Tmem218

Diseases

1 with Tmem218 mouse models; 1 with human TMEM218 associations

Human Disease

Mouse Models

Senior-Loken syndrome

IDs

View 1 model

Joubert syndrome

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

16 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

1
Gene trapped

4
Targeted

3
Find Mice (IMSR)

5 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice show progressive cystic kidney disease and retinal degeneration.

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All GO Annotations

2
GO References

1

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

617
Tissues

4
cDNA Data

30
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem218

ZFIN tmem218

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All Sequences

40
RefSeq

6
UniProt

1
CCDS

CCDS22975.1

Ensembl

ENSMUSG00000032121 (Evidence)
NCBI Gene

66279

			Length	Strain/Species	Flank
genomic	66279	NCBI Gene Model \| MGI Sequence Detail	15006	C57BL/6J	± kb
transcript	NM_025464	RefSeq \| MGI Sequence Detail	1167	C57BL/6
polypeptide	Q9CQ44	UniProt \| EBI \| MGI Sequence Detail	115	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000031151 transmembrane protein 218

(term hierarchy)
InterPro Domains

IPR026771 Transmembrane protein 218

IPR057973 Transmembrane protein 218, N-terminal domain

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All nucleic 31

cDNA 30

Primer pair 1

Microarray probesets 4

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MGI:2143246

Summaries

All 31

Developmental Gene Expression 1

Diseases 1

Gene Ontology 1

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:282558 Collin GB, et al., Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss. Cells. 2020 Apr 10;9(4):931

TSS for Tmem218:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84374	Chr9:37119472-37119491 (+)	-37 bp
Tssr84375	Chr9:37119587-37119656 (+)	103 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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