Cox16 MGI Mouse Gene Detail - MGI:1913522 - cytochrome c oxidase assembly protein 16

Symbol

Cox16
Name

cytochrome c oxidase assembly protein 16
Synonyms

1810020G14Rik, 1810055I05Rik

Feature Type

protein coding gene
IDs

MGI:1913522
NCBI Gene: 66272
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr12:81405800-81531901 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 37.60 cM, cytoband D2
Mapping Data

3 experiments

SNPs within 2kb

119 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913522	protein coding gene	Chr12:81405626-81531911 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019900	protein coding gene	Chr12:81811561-81944837 (-)
A/J	MGP_AJ_G0019858	protein coding gene	Chr12:78811268-78954351 (-)
AKR/J	MGP_AKRJ_G0019833	protein coding gene	Chr12:80977700-81109772 (-)
BALB/cJ	MGP_BALBcJ_G0019837	protein coding gene	Chr12:79052086-79182414 (-)
C3H/HeJ	MGP_C3HHeJ_G0019643	protein coding gene	Chr12:81433849-81566436 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020289	protein coding gene	Chr12:84188196-84344504 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017908	protein coding gene	Chr12:75900687-75915359 (-)
CAST/EiJ	MGP_CASTEiJ_G0019193	protein coding gene	Chr12:76301286-76443813 (-)
CBA/J	MGP_CBAJ_G0019614	protein coding gene	Chr12:87453870-87610192 (-)
DBA/2J	MGP_DBA2J_G0019729	protein coding gene	Chr12:78403713-78535391 (-)
FVB/NJ	MGP_FVBNJ_G0019715	protein coding gene	Chr12:77240941-77393985 (-)
LP/J	MGP_LPJ_G0019801	protein coding gene	Chr12:81708865-81858438 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019754	protein coding gene	Chr12:90451288-90612274 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020324	protein coding gene	Chr12:80493180-80638702 (-)
PWK/PhJ	MGP_PWKPhJ_G0018959	protein coding gene	Chr12:72821267-72947442 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018753	protein coding gene	Chr12:75016886-75140309 (-)
WSB/EiJ	MGP_WSBEiJ_G0019246	protein coding gene	Chr12:81136388-81281559 (-)

Human Ortholog

COX16, cytochrome c oxidase assembly factor COX16

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

COX16, cytochrome c oxidase assembly factor COX16
Synonyms

C14orf112, hCOX16, HSPC203, MC4DN22
Links

HGNC:20213

NCBI Gene ID: 51241

neXtProt AC: NX_Q9P0S2

UniProt: Q9P0S2
Chr Location

14q24.2; chr14:70325081-70359731 (-) GRCh38.p7

Alliance of Genome Resources

Cox16 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: COX16
Gene Tree

Cox16

less

Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Targeted

1
Genomic Mutations

1 involving Cox16
Find Mice (IMSR)

20 strains or lines available

less

All GO Annotations

6
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

713
Tissues

7
cDNA Data

18
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cox16

ZFIN cox16

less

Cox16 interacts with 196 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

less

All Sequences

72
RefSeq

10
UniProt

5
CCDS

CCDS26020.1, CCDS83976.1, CCDS83977.1, CCDS83978.1

Ensembl

ENSMUSG00000091803 (Evidence)
NCBI Gene

66272

			Length	Strain/Species	Flank
genomic	ENSMUSG00000091803	Ensembl Gene Model \| MGI Sequence Detail	126102	C57BL/6J	± kb
transcript	ENSMUST00000002757	Ensembl \| MGI Sequence Detail	2007	Not Applicable
polypeptide	ENSMUSP00000002757	Ensembl \| MGI Sequence Detail	106	Not Applicable

less

UniProt

5 Sequences
Protein Ontology

PR:000005772 cytochrome c oxidase assembly protein COX16, mitochondrial

(term hierarchy)
InterPro Domains

IPR020164 Cytochrome c oxidase assembly protein COX16

less

All nucleic 21

cDNA 20

Other 1

Microarray probesets 7

less

MGI:1922914, MGI:3034740

Summaries

All 35

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

TSS for Cox16:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr116925	Chr12:81531849-81531914 (-)	19 bp
Tssr116924	Chr12:81531801-81531839 (-)	81 bp
Tssr116923	Chr12:81522122-81522129 (-)	9,775 bp
Tssr116922	Chr12:81519038-81519050 (-)	12,857 bp
Tssr116921	Chr12:81503700-81503701 (-)	28,200 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Copyright, and Privacy Statement Send questions and comments to User Support.	last database update 01/24/2023 MGI 6.22