Tm4sf20 MGI Mouse Gene Detail - MGI:1913511 - transmembrane 4 L six family member 20

Symbol

Tm4sf20
Name

transmembrane 4 L six family member 20
Synonyms

1810018L02Rik

Feature Type

protein coding gene
IDs

MGI:1913511
NCBI Gene: 66261
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr1:82734370-82746182 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 42.48 cM, cytoband C5
Mapping Data

2 experiments

SNPs within 2kb

416 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913511	protein coding gene	Chr1:82734368-82746182 (-)
129S1/SvImJ	ENSMUSG00200032747	protein coding gene	Chr1:80408409-80420222 (-)
A/J	ENSMUSG00195010416	protein coding gene	Chr1:79810880-79822695 (-)
AKR/J	ENSMUSG00220010407	protein coding gene	Chr1:80005327-80017191 (-)
BALB/cJ	ENSMUSG00180016398	protein coding gene	Chr1:80082605-80094417 (-)
C3H/HeJ	ENSMUSG00175015104	protein coding gene	Chr1:80217041-80228854 (-)
C57BL/6NJ	ENSMUSG00215009106	protein coding gene	Chr1:80130772-80142586 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014330	protein coding gene	Chr1:75931671-75944350 (-)
CAST/EiJ	ENSTCUG00005028114	protein coding gene	Chr1:79799205-79811007 (-)
CBA/J	ENSMUSG00210037637	protein coding gene	Chr1:80002857-80014720 (-)
DBA/2J	ENSMUSG00185029325	protein coding gene	Chr1:81039428-81051240 (-)
FVB/NJ	ENSMUSG00205025603	protein coding gene	Chr1:79553399-79565254 (-)
JF1/MsJ	ENSUMUG00000003784	protein coding gene	Chr1:79843349-79855892 (-)
LP/J	ENSMUSG00230008609	protein coding gene	Chr1:80975607-80987420 (-)
NOD/ShiLtJ	ENSMUSG00190024711	protein coding gene	Chr1:80206403-80218266 (-)
NZO/HlLtJ	ENSMUSG00225002170	protein coding gene	Chr1:84220929-84232741 (-)
PWK/PhJ	ENSLUMG00010012286	protein coding gene	Chr1:79468217-79480715 (-)
SPRET/EiJ	ENSMSPG00010018648	protein coding gene	Chr1:81607983-81619221 (-)
WSB/EiJ	ENSIUOG00005013695	protein coding gene	Chr1:79773600-79785473 (-)

Human Ortholog

TM4SF20, transmembrane 4 L six family member 20

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TM4SF20, transmembrane 4 L six family member 20
Synonyms

PRO994, SLI5, TCCE518
Links

HGNC:26230

NCBI Gene ID: 79853

UniProt: Q53R12
Chr Location

2q36.3; chr2:227362038-227381995 (-) GRCh38

MGI Vertebrate Homology

Tm4sf20 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TM4SF20
Gene Tree

Tm4sf20

Diseases

1 with human TM4SF20 associations

				Human Disease	Mouse Models
				specific language impairment IDs specific language impairment DOID:0060244 OMIM:606711 OMIM:606712 OMIM:607134 OMIM:612514 OMIM:615432

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

3
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Tm4sf20
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

14
GO References

6

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

695
Tissues

34
cDNA Data

23
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tm4sf20

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All Sequences

38
RefSeq

4
UniProt

1
CCDS

CCDS15099.1

Ensembl

ENSMUSG00000026149 (Evidence)
NCBI Gene

66261

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026149	Ensembl Gene Model \| MGI Sequence Detail	11813	C57BL/6J	± kb
transcript	ENSMUST00000027331	Ensembl \| MGI Sequence Detail	1508	Not Applicable
polypeptide	ENSMUSP00000027331	Ensembl \| MGI Sequence Detail	226	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000031923 transmembrane 4 L6 family member 20

(term hierarchy)
InterPro Domains

IPR008661 L6 membrane

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All nucleic 24

cDNA 23

Primer pair 1

Microarray probesets 4

Summaries

All 46

Developmental Gene Expression 5

Gene Ontology 6

Phenotypes 16
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tm4sf20:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr12523	Chr1:82746170-82746186 (-)	4 bp
Tssr12522	Chr1:82744932-82744936 (-)	1,248 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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