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Nenf Gene Detail
Summary
  • Symbol
    Nenf
  • Name
    neuron derived neurotrophic factor
  • Synonyms
    1110060M21Rik, neudesin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913458
    NCBI Gene: 66208
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:191038984-191050328 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 96.28 cM, cytoband H6
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    79 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913458
 protein coding gene Chr1:191038984-191050391 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016942
 protein coding gene Chr1:198340864-198352020 (-)
A/J MGP_AJ_G0016921
 protein coding gene Chr1:190210916-190222837 (-)
AKR/J MGP_AKRJ_G0016886
 protein coding gene Chr1:195856693-195872436 (-)
BALB/cJ MGP_BALBcJ_G0016879
 protein coding gene Chr1:190889859-190901672 (-)
C3H/HeJ MGP_C3HHeJ_G0016703
 protein coding gene Chr1:196697984-196711134 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017342
 protein coding gene Chr1:204658058-204673008 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015049
 protein coding gene Chr1:181109773-181120269 (-)
CAST/EiJ MGP_CASTEiJ_G0016286
 protein coding gene Chr1:196301464-196313426 (-)
CBA/J MGP_CBAJ_G0016677
 protein coding gene Chr1:212240075-212257153 (-)
DBA/2J MGP_DBA2J_G0016783
 protein coding gene Chr1:188938363-188950059 (-)
FVB/NJ MGP_FVBNJ_G0016779
 protein coding gene Chr1:187061828-187073006 (-)
LP/J MGP_LPJ_G0016858
 protein coding gene Chr1:199523450-199537268 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016811
 protein coding gene Chr1:218946290-218959144 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017379
 protein coding gene Chr1:195725676-195736755 (-)
PWK/PhJ MGP_PWKPhJ_G0016073
 protein coding gene Chr1:188223043-188234627 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015849
 protein coding gene Chr1:194736216-194751862 (-)
WSB/EiJ MGP_WSBEiJ_G0016348
 protein coding gene Chr1:195950425-195962991 (-)



Homology
more
  • Human Ortholog
    NENF, neudesin neurotrophic factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NENF, neudesin neurotrophic factor
  • Synonyms
    CIR2, SCIRP10, SPUF
  • Links
    NCBI Gene ID: 29937
    neXtProt AC: NX_Q9UMX5
    UniProt: Q9UMX5

  • Chr Location
    1q32.3; chr1:212432920-212446379 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased anxiety-related response, abnormal dendrite morphology and decreased dopamine levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    29
  • cDNA Data
    29
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 66208 NCBI Gene Model | MGI Sequence Detail 11345 C57BL/6J ±  kb
transcript NM_025424 RefSeq | MGI Sequence Detail 681 C57BL/6  
polypeptide Q9CQ45 UniProt | EBI | MGI Sequence Detail 171 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 32
    cDNA 29
    Primer pair 2
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 35
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:282679 Moutaoufik MT, et al., Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis. iScience. 2019 Sep 27;19:1114-1132
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory