Virma MGI Mouse Gene Detail - MGI:1913435 - vir like m6A methyltransferase associated

Symbol

Virma
Name

vir like m6A methyltransferase associated
Synonyms

1110037F02Rik, 4930422M05Rik, mKIAA1429

Feature Type

protein coding gene
IDs

MGI:1913435
NCBI Gene: 66185
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr4:11485958-11550684 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 5.11 cM, cytoband A2
Mapping Data

2 experiments

SNPs within 2kb

470 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913435	protein coding gene	Chr4:11485958-11551143 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028053	protein coding gene	Chr4:8152355-8220200 (+)
A/J	MGP_AJ_G0028010	protein coding gene	Chr4:8024220-8089159 (+)
AKR/J	MGP_AKRJ_G0027976	protein coding gene	Chr4:8113224-8177899 (+)
BALB/cJ	MGP_BALBcJ_G0028022	protein coding gene	Chr4:7951705-8016629 (+)
C3H/HeJ	MGP_C3HHeJ_G0027752	protein coding gene	Chr4:8283693-8351018 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028465	protein coding gene	Chr4:8557483-8630923 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025809	protein coding gene	Chr4:7533794-7599746 (+)
CAST/EiJ	MGP_CASTEiJ_G0027206	protein coding gene	Chr4:8097417-8164631 (+)
CBA/J	MGP_CBAJ_G0027727	protein coding gene	Chr4:8794767-8867388 (+)
DBA/2J	MGP_DBA2J_G0027868	protein coding gene	Chr4:7894496-7960164 (+)
FVB/NJ	MGP_FVBNJ_G0027834	protein coding gene	Chr4:7724840-7790967 (+)
LP/J	MGP_LPJ_G0027978	protein coding gene	Chr4:8236824-8303718 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027867	protein coding gene	Chr4:8978030-9049169 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028524	protein coding gene	Chr4:8116941-8184530 (+)
PWK/PhJ	MGP_PWKPhJ_G0026927	protein coding gene	Chr4:7907421-7975295 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026757	protein coding gene	Chr4:8025126-8093486 (+)
WSB/EiJ	MGP_WSBEiJ_G0027285	protein coding gene	Chr4:8177820-8243965 (+)

Human Ortholog

VIRMA, vir like m6A methyltransferase associated

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

VIRMA, vir like m6A methyltransferase associated
Synonyms

fSAP121, KIAA1429, MSTP054
Links

HGNC:24500

NCBI Gene ID: 25962

neXtProt AC: NX_Q69YN4

UniProt: Q69YN4
Chr Location

8q22.1; chr8:94487689-94553529 (-) GRCh38

MGI Vertebrate Homology

Virma stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: VIRMA
Gene Tree

Virma

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

43
Endonuclease-mediated

3
Gene trapped

37
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

106 strains or lines available

Mice homozygous for a knock-out allele exhibit abnormal trophoblast layer formation, partial embryonic during organogenesis and complete lethality by E14.5.

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All GO Annotations

18
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

164

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase virma

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All Sequences

47
RefSeq

4
UniProt

3
CCDS

CCDS38693.1, CCDS84705.1

Ensembl

ENSMUSG00000040720 (Evidence)
NCBI Gene

66185

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040720	Ensembl Gene Model \| MGI Sequence Detail	64727	C57BL/6J	± kb
transcript	ENSMUST00000108307	Ensembl \| MGI Sequence Detail	6571	Not Applicable
polypeptide	ENSMUSP00000103943	Ensembl \| MGI Sequence Detail	1861	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000060152 protein virilizer homolog

(term hierarchy)
InterPro Domains

IPR026736 Protein virilizer

IPR031801 Virilizer, N-terminal

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All nucleic 164

cDNA 164

Microarray probesets 7

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MGI:2442597

Summaries

All 45

Gene Ontology 8

Phenotypes 14
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:333887 Wu Y, et al., N(6)-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition. Nat Cell Biol. 2022 Jun;24(6):917-927

TSS for Virma:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr36481	Chr4:11485947-11485964 (+)	-2 bp
Tssr36482	Chr4:11485966-11485973 (+)	12 bp
Tssr36483	Chr4:11486002-11486045 (+)	66 bp
Tssr36484	Chr4:11535281-11535285 (+)	49,325 bp
Tssr36485	Chr4:11546068-11546095 (+)	60,124 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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