Nop10 MGI Mouse Gene Detail - MGI:1913431

Symbol

Nop10
Name

NOP10 ribonucleoprotein
Synonyms

1110036B12Rik, H/ACA small nucleolar RNPs, Nola3, NOP10P

Feature Type

protein coding gene
IDs

MGI:1913431
NCBI Gene: 66181
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr2:112092271-112093243 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 56.99 cM, cytoband E4
Mapping Data

2 experiments

SNPs within 2kb

2 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913431	protein coding gene	Chr2:112092271-112093614 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026286	protein coding gene	Chr2:114706285-114707630 (+)
A/J	MGP_AJ_G0026247	protein coding gene	Chr2:110006446-110007791 (+)
AKR/J	MGP_AKRJ_G0026226	protein coding gene	Chr2:113097032-113098377 (+)
BALB/cJ	MGP_BALBcJ_G0026260	protein coding gene	Chr2:110274027-110275372 (+)
C3H/HeJ	MGP_C3HHeJ_G0026005	protein coding gene	Chr2:113490475-113491821 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026707	protein coding gene	Chr2:118509085-118510428 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024087	protein coding gene	Chr2:105239508-105240874 (+)
CAST/EiJ	MGP_CASTEiJ_G0025466	protein coding gene	Chr2:113682042-113683385 (-)
CBA/J	MGP_CBAJ_G0025982	protein coding gene	Chr2:122639974-122641319 (+)
DBA/2J	MGP_DBA2J_G0026121	protein coding gene	Chr2:109462402-109463747 (+)
FVB/NJ	MGP_FVBNJ_G0026083	protein coding gene	Chr2:108350035-108351380 (+)
LP/J	MGP_LPJ_G0026222	protein coding gene	Chr2:114990654-114991999 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026102	protein coding gene	Chr2:127042825-127044170 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026762	protein coding gene	Chr2:113163925-113165270 (+)
PWK/PhJ	MGP_PWKPhJ_G0025204	protein coding gene	Chr2:108971136-108972481 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025003	protein coding gene	Chr2:112352602-112355998 (+)
WSB/EiJ	MGP_WSBEiJ_G0025537	protein coding gene	Chr2:113972743-113974086 (+)

Human Ortholog

NOP10, NOP10 ribonucleoprotein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NOP10, NOP10 ribonucleoprotein
Synonyms

CHINE2, DKCB1, NOLA3, NOP10P, PFBMFT9
Links

HGNC:14378

NCBI Gene ID: 55505

neXtProt AC: NX_Q9NPE3

UniProt: Q9NPE3
Chr Location

15q14; chr15:34339159-34343180 (-) GRCh38

MGI Vertebrate Homology

Nop10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NOP10
Gene Tree

Nop10

Diseases

1 with human NOP10 associations

				Human Disease	Mouse Models
				autosomal recessive dyskeratosis congenita 1 IDs autosomal recessive dyskeratosis congenita 1 DOID:0070015 OMIM:224230

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

9
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Nop10
Find Mice (IMSR)

6 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

23
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

758
Tissues

45
cDNA Data

87
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nop10

ZFIN nop10

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All Sequences

29
RefSeq

2
UniProt

1
CCDS

CCDS38198.1

Ensembl

ENSMUSG00000027133 (Evidence)
NCBI Gene

66181

			Length	Strain/Species	Flank
genomic	66181	NCBI Gene Model \| MGI Sequence Detail	973	C57BL/6J	± kb
transcript	NM_025403	RefSeq \| MGI Sequence Detail	738	C57BL/6
polypeptide	Q9CQS2	UniProt \| EBI \| MGI Sequence Detail	64	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000011321 H/ACA ribonucleoprotein complex subunit 3

(term hierarchy)
InterPro Domains

IPR007264 H/ACA ribonucleoprotein complex, subunit Nop10

IPR036756 H/ACA ribonucleoprotein complex, subunit Nop10 superfamily

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All nucleic 87

cDNA 87

Microarray probesets 4

Summaries

All 41

Developmental Gene Expression 1

Gene Ontology 9

Phenotypes 12
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

TSS for Nop10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19348	Chr2:112092290-112092296 (+)	22 bp
Tssr19349	Chr2:112092302-112092319 (+)	40 bp
Tssr19350	Chr2:112092673-112092682 (+)	407 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23