Rtl8a Gene Detail

Summary

• Symbol
  Rtl8a
• Name
  retrotransposon Gag like 8A
• Synonyms
  1110012O05Rik, Cxx1a, Mar8.2A/B, Mart8b

• Feature Type
  protein coding gene
• IDs
  MGI:1913408
  NCBI Gene: 66158
• Alliance
  genome feature page
• Transcription Start Sites
  2 TSS

Location &
Maps

• Sequence Map
  ChrX:52644455-52645649 bp, - strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome X, 29.87 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  96 from dbSNP Build 142
• Strain Annotations
  6

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913408	protein coding gene	ChrX:52644455-52645730 (-)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	no annotation
BALB/cJ	no annotation
C3H/HeJ	ENSMUSG00175039119	protein coding gene	ChrX:40076421-40077615 (-)
C57BL/6NJ	no annotation
CAROLI/EiJ	MGP_CAROLIEiJ_G0033076	protein coding gene	ChrX:46200774-46201980 (-)
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	ENSMUSG00205028846	protein coding gene	ChrX:35632219-35633413 (-)
JF1/MsJ	no annotation
LP/J	ENSMUSG00230027875	protein coding gene	ChrX:54577944-54579176 (-)
NOD/ShiLtJ	no annotation
NZO/HlLtJ	no annotation
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	ENSIUOG00005046693	protein coding gene	ChrX:37549051-37550245 (-)

Homology

• Human Ortholog
  RTL8A, retrotransposon Gag like 8A

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  RTL8A, retrotransposon Gag like 8A
  
• Synonyms
  CXX1b, FAM127B, MAR8A, SIRH6
• Links
  HGNC:24514

  NCBI Gene ID: 26071

  UniProt: Q9BWD3

  
  
• Chr Location
  Xq26.3; chrX:135050932-135052196 (-)  GRCh38

---

• Human Ortholog
  RTL8B, retrotransposon Gag like 8B
  
• Synonyms
  CXX1c, FAM127C, MAR8B, SIRH4
• Links
  HGNC:33156

  NCBI Gene ID: 441518

  UniProt: Q17RB0

  
  
• Chr Location
  Xq26.3; chrX:135020513-135022542 (-)  GRCh38

---

• Human Ortholog
  RTL8C, retrotransposon Gag like 8C
  
• Synonyms
  CXX1, FAM127A, Mar8, MAR8C, Mart8, MART8C, SIRH5
• Links
  HGNC:2569

  NCBI Gene ID: 8933

  UniProt: A6ZKI3

  
  
• Chr Location
  Xq26.3; chrX:135032355-135033546 (+)  GRCh38

---

• MGI Vertebrate Homology
  Rtl8a stringent orthology
  3 human;1 mouse;1 rat
  
• HCOP
  vertebrate homology predictions: RTL8A, RTL8B, RTL8C
• Gene Tree
  Rtl8a
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype reference
  

• All Mutations and Alleles
  1
• Endonuclease-mediated
  1
• Find Mice (IMSR)
  1 strains or lines available

Expression

• Assay Results
  691
• Tissues
  16
• cDNA Data
  3
• Literature Summary
  2

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  15
• RefSeq
  2
• CCDS
  CCDS30134.1

• Ensembl
  ENSMUSG00000067925 (Evidence)
• NCBI Gene
  66158

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000067925	Ensembl Gene Model | MGI Sequence Detail	1195	C57BL/6J
transcript	ENSMUST00000088779	Ensembl | MGI Sequence Detail	1195	Not Applicable
polypeptide	ENSMUSP00000086158	Ensembl | MGI Sequence Detail	113	Not Applicable

Molecular
Reagents

• All nucleic 4

  cDNA 4

  
  

  Microarray probesets 2

Other
Accession IDs

MGI:5906153

References

• Summaries
  All 19

  Developmental Gene Expression 2

  Phenotypes 1
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:336757 Mohan HM, et al., RTL8 promotes nuclear localization of UBQLN2 to subnuclear compartments associated with protein quality control. Cell Mol Life Sci. 2022 Mar 5;79(3):176

TSS for Rtl8a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr163399	ChrX:52645738-52645745 (-)	-93 bp
Tssr163398	ChrX:52645684-52645736 (-)	-61 bp