Fmc1 Gene Detail

Summary

• Symbol
  Fmc1
• Name
  formation of mitochondrial complex V assembly factor 1
• Synonyms
  1110001J03Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1913367
  NCBI Gene: 66117
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr6:38511796-38516384 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 6, 17.84 cM, cytoband B1
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  37 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913367	protein coding gene	Chr6:38510437-38516384 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030587	protein coding gene	Chr6:36858832-36864779 (+)
A/J	MGP_AJ_G0030560	protein coding gene	Chr6:35246516-35252463 (+)
AKR/J	MGP_AKRJ_G0030487	protein coding gene	Chr6:36371173-36377120 (+)
BALB/cJ	MGP_BALBcJ_G0030570	protein coding gene	Chr6:35447358-35454394 (+)
C3H/HeJ	MGP_C3HHeJ_G0030283	protein coding gene	Chr6:36382693-36388640 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031024	protein coding gene	Chr6:37774609-37780556 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028236	protein coding gene	Chr6:33151959-33158000 (+)
CAST/EiJ	MGP_CASTEiJ_G0029685	protein coding gene	Chr6:36274245-36280232 (+)
CBA/J	MGP_CBAJ_G0030261	protein coding gene	Chr6:39237392-39243561 (+)
DBA/2J	MGP_DBA2J_G0030405	protein coding gene	Chr6:35065293-35071240 (+)
FVB/NJ	MGP_FVBNJ_G0030359	protein coding gene	Chr6:34855247-34861194 (+)
LP/J	MGP_LPJ_G0030492	protein coding gene	Chr6:36889094-36895263 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030395	protein coding gene	Chr6:41603261-41609208 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031054	protein coding gene	Chr6:36303174-36309343 (+)
PWK/PhJ	MGP_PWKPhJ_G0029399	protein coding gene	Chr6:34730372-34736310 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029235	protein coding gene	Chr6:36026960-36032851 (+)
WSB/EiJ	MGP_WSBEiJ_G0029761	protein coding gene	Chr6:36242055-36248002 (+)

Homology

• Human Ortholog
  FMC1, formation of mitochondrial complex V assembly factor 1 homolog

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  FMC1, formation of mitochondrial complex V assembly factor 1 homolog
  
• Synonyms
  C7orf55, HSPC268
• Links
  HGNC:26946

  NCBI Gene ID: 154791

  neXtProt AC: NX_Q96HJ9

  UniProt: Q96HJ9

  
  
• Chr Location
  7q34; chr7:139339457-139346328 (+)  GRCh38

---

• Human Ortholog
  FMC1-LUC7L2, FMC1-LUC7L2 readthrough
  
• Synonyms
  C7orf55, C7orf55-LUC7L2, FMC1
• Links
  HGNC:44671

  NCBI Gene ID: 100996928

  neXtProt AC: NX_Q96HJ9

  
  
• Chr Location
  7q34; chr7:139341337-139423454 (+)  GRCh38

---

• MGI Vertebrate Homology
  Fmc1 stringent orthology
  2 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: FMC1, FMC1-LUC7L2
• Gene Tree
  Fmc1
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  10 phenotypes from 2 alleles in 2 genetic backgrounds
  14 phenotype references
  

• All Mutations and Alleles
  75
• Endonuclease-mediated
  3
• Gene trapped
  68
• Targeted
  4
• Find Mice (IMSR)
  19 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Mice homozygous for a null allele exhibit postnatal lethality. Mice heterozygous for a null allele exhibit resistance to MPTP-induced parkinsonism.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  6
• GO References
  5

Expression

• Assay Results
  724
• Tissues
  18
• cDNA Data
  6
• Literature Summary
  2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase fmc1

Sequences &
Gene Models

• All Sequences
  31
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS20014.1

• Ensembl
  ENSMUSG00000019689 (Evidence)
• NCBI Gene
  66117

Representative Sequences			Length	Strain/Species
genomic	66117	NCBI Gene Model | MGI Sequence Detail	4589	C57BL/6J
transcript	NM_025363	RefSeq | MGI Sequence Detail	441	C57BL/6
polypeptide	Q9CR13	UniProt | EBI | MGI Sequence Detail	113	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• InterPro Domains
  IPR037667 Protein FMC1 homologue

Molecular
Reagents

• All nucleic 6

  cDNA 6

  
  

  Microarray probesets 3

References

• Summaries
  All 37

  Developmental Gene Expression 2

  Gene Ontology 5

  Phenotypes 14
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:257586 Inoue N, et al., Knockdown of the mitochondria-localized protein p13 protects against experimental parkinsonism. EMBO Rep. 2018 Mar;19(3)

TSS for Fmc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr55653	Chr6:38511768-38511807 (+)	-8 bp