Kcnmb4 MGI Mouse Gene Detail - MGI:1913272 - potassium large conductance calcium-activated channel, subfamily M, beta member 4

Symbol

Kcnmb4
Name

potassium large conductance calcium-activated channel, subfamily M, beta member 4
Synonyms

2900045G12Rik, Slowpoke beta 4

Feature Type

protein coding gene
IDs

MGI:1913272
NCBI Gene: 58802
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:116253766-116309782 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 64.73 cM, cytoband D2
Mapping Data

3 experiments

SNPs within 2kb

493 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913272	protein coding gene	Chr10:116253766-116309783 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017745	protein coding gene	Chr10:119191261-119252694 (-)
A/J	MGP_AJ_G0017721	protein coding gene	Chr10:114607822-114665822 (-)
AKR/J	MGP_AKRJ_G0017683	protein coding gene	Chr10:117929912-117987136 (-)
BALB/cJ	MGP_BALBcJ_G0017684	protein coding gene	Chr10:115008474-115067702 (-)
C3H/HeJ	MGP_C3HHeJ_G0017509	protein coding gene	Chr10:118154992-118221420 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018141	protein coding gene	Chr10:123336402-123397224 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015821	protein coding gene	Chr10:109211066-109267318 (-)
CAST/EiJ	MGP_CASTEiJ_G0017071	protein coding gene	Chr10:118431177-118499838 (-)
CBA/J	MGP_CBAJ_G0017478	protein coding gene	Chr10:128158506-128227862 (-)
DBA/2J	MGP_DBA2J_G0017583	protein coding gene	Chr10:113749397-113806076 (-)
FVB/NJ	MGP_FVBNJ_G0017578	protein coding gene	Chr10:112704216-112761579 (-)
LP/J	MGP_LPJ_G0017658	protein coding gene	Chr10:119775775-119837160 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017607	protein coding gene	Chr10:131064537-131126345 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018179	protein coding gene	Chr10:117995064-118057264 (-)
PWK/PhJ	MGP_PWKPhJ_G0016853	protein coding gene	Chr10:113834330-113892631 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016643	protein coding gene	Chr10:116802869-116865433 (-)
WSB/EiJ	MGP_WSBEiJ_G0017131	protein coding gene	Chr10:118174873-118233580 (-)

Human Ortholog

KCNMB4, potassium calcium-activated channel subfamily M regulatory beta subunit 4

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KCNMB4, potassium calcium-activated channel subfamily M regulatory beta subunit 4
Links

HGNC:6289

NCBI Gene ID: 27345

neXtProt AC: NX_Q86W47

UniProt: Q86W47
Chr Location

12q15; chr12:70366220-70434292 (+) GRCh38.p7

Alliance of Genome Resources

Kcnmb4 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: KCNMB4
Gene Tree

Kcnmb4

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Phenotype Summary

6 phenotypes from 3 alleles in 4 genetic backgrounds
1 phenotype from multigenic genotypes
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

2
Genomic Mutations

1 involving Kcnmb4
Incidental Mutations

APF
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in no obvious phenotype.

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All GO Annotations

21
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

843
Tissues

33
cDNA Data

7
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kcnmb4

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Kcnmb4 interacts with 196 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

39
RefSeq

6
UniProt

1
CCDS

CCDS24184.1

Ensembl

ENSMUSG00000054934 (Evidence)
NCBI Gene

58802

			Length	Strain/Species	Flank
genomic	58802	NCBI Gene Model \| MGI Sequence Detail	56017	C57BL/6J	± kb
transcript	NM_021452	RefSeq \| MGI Sequence Detail	1032	BALB/c
polypeptide	Q9JIN6	UniProt \| EBI \| MGI Sequence Detail	210	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000009269 calcium-activated potassium channel subunit beta-4

(term hierarchy)
InterPro Domains

IPR003930 Potassium channel, calcium-activated, BK, beta subunit

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All nucleic 8

cDNA 8

Microarray probesets 3

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MGI:1920173

Summaries

All 57

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 23
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:327338 Sartoretti MM, et al., Dbx1 controls the development of astrocytes of the intermediate spinal cord by modulating Notch signaling. Development. 2022 Aug 1;149(15):dev200750

TSS for Kcnmb4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr99354	Chr10:116309780-116309834 (-)	-25 bp
Tssr99353	Chr10:116309533-116309549 (-)	241 bp
Tssr99352	Chr10:116309450-116309466 (-)	324 bp
Tssr99351	Chr10:116309323-116309419 (-)	411 bp
Tssr99350	Chr10:116309300-116309311 (-)	476 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Copyright, and Privacy Statement Send questions and comments to User Support.	last database update 01/31/2023 MGI 6.22