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Ms4a4b Gene Detail
Summary
  • Symbol
    Ms4a4b
  • Name
    membrane-spanning 4-domains, subfamily A, member 4B
  • Synonyms
    Chandra, Ly116
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913083
    NCBI Gene: 60361
  • Member of
    Ms4ac cluster
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:11420922-11440913 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 8.44 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    104 from dbSNP Build 142
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913083
 protein coding gene Chr19:11420917-11444419 (+)
129S1/SvImJ no annotation
A/J MGP_AJ_G0024847
 protein coding gene Chr19:8283744-8380707 (+)
AKR/J MGP_AKRJ_G0024822
 protein coding gene Chr19:8602748-8758861 (+)
BALB/cJ MGP_BALBcJ_G0024847
 protein coding gene Chr19:8300773-8380804 (+)
C3H/HeJ MGP_C3HHeJ_G0024613
 protein coding gene Chr19:8470956-8655594 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025295
 protein coding gene Chr19:9234360-9294563 (+)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0024587
 protein coding gene Chr19:9299606-9335635 (+)
DBA/2J MGP_DBA2J_G0024714
 protein coding gene Chr19:8280368-8353725 (+)
FVB/NJ MGP_FVBNJ_G0024681
 protein coding gene Chr19:8284876-8446041 (+)
LP/J MGP_LPJ_G0024801
 protein coding gene Chr19:8793197-8893060 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024708
 protein coding gene Chr19:9201791-9292024 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025343
 protein coding gene Chr19:8604456-8670737 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0024148
 protein coding gene Chr19:8482325-8600132 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    35
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 60361 NCBI Gene Model | MGI Sequence Detail 19992 C57BL/6J ±  kb
transcript NM_021718 RefSeq | MGI Sequence Detail 1282 C57BL/6  
polypeptide NP_068364 RefSeq | MGI Sequence Detail 226 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • InterPro Domains
    IPR007237 CD20-like family
    IPR030417 Membrane-spanning 4-domains subfamily A
Molecular
Reagents
less
  • All nucleic 35
    cDNA 35

    Microarray probesets 5
Other
Accession IDs
less
MGI:2147556
References
more
  • Summaries
    All 30
    Gene Ontology 2
    Phenotypes 3
  • Earliest
    J:65151 Venkataraman C, et al., Cutting edge: Chandra, a novel four-transmembrane domain protein differentially expressed in helper type 1 lymphocytes. J Immunol. 2000 Jul 15;165(2):632-6
  • Latest
    J:188168 Yan Y, et al., TCR stimulation upregulates MS4a4B expression through induction of AP-1 transcription factor during T cell activation. Mol Immunol. 2012 Sep;52(2):71-8
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory