Ncbp1 MGI Mouse Gene Detail - MGI:1891840 - nuclear cap binding protein subunit 1

Symbol

Ncbp1
Name

nuclear cap binding protein subunit 1

Feature Type

protein coding gene
IDs

MGI:1891840
NCBI Gene: 433702
Alliance

genome feature page
Transcription Start Sites

7 TSS

Sequence Map

Chr4:46138732-46172403 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 24.49 cM
Mapping Data

2 experiments

SNPs within 2kb

824 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891840	protein coding gene	Chr4:46138613-46172403 (+)
129S1/SvImJ	ENSMUSG00200003069	protein coding gene	Chr4:42194334-42228110 (+)
A/J	ENSMUSG00195006196	protein coding gene	Chr4:42648120-42681896 (+)
AKR/J	ENSMUSG00220002580	protein coding gene	Chr4:42340076-42373866 (+)
BALB/cJ	ENSMUSG00180027635	protein coding gene	Chr4:42234784-42268562 (+)
C3H/HeJ	ENSMUSG00175020410	protein coding gene	Chr4:42384268-42418042 (+)
C57BL/6NJ	ENSMUSG00215015066	protein coding gene	Chr4:42163312-42197108 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025982	protein coding gene	Chr4:40201740-40235745 (+)
CAST/EiJ	ENSTCUG00005037020	protein coding gene	Chr4:42400408-42433968 (+)
CBA/J	ENSMUSG00210019137	protein coding gene	Chr4:42071209-42104983 (+)
DBA/2J	ENSMUSG00185031037	protein coding gene	Chr4:42434615-42468389 (+)
FVB/NJ	ENSMUSG00205020036	protein coding gene	Chr4:41731147-41764940 (+)
JF1/MsJ	ENSUMUG00000035654	protein coding gene	Chr4:42653219-42686918 (+)
LP/J	ENSMUSG00230038907	protein coding gene	Chr4:45995335-46029109 (+)
NOD/ShiLtJ	ENSMUSG00190022811	protein coding gene	Chr4:42298170-42331960 (+)
NZO/HlLtJ	ENSMUSG00225006964	protein coding gene	Chr4:50590950-50624738 (+)
PWK/PhJ	ENSLUMG00010011968	protein coding gene	Chr4:41665522-41699310 (+)
SPRET/EiJ	ENSMSPG00010008280	protein coding gene	Chr4:42585322-42619813 (+)
WSB/EiJ	ENSIUOG00005004155	protein coding gene	Chr4:42047111-42080927 (+)

Human Ortholog

NCBP1, nuclear cap binding protein subunit 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NCBP1, nuclear cap binding protein subunit 1
Synonyms

CBP80, NCBP, Sto1
Links

HGNC:7658

NCBI Gene ID: 4686

UniProt: Q09161
Chr Location

9q22.33; chr9:97633448-97673748 (+) GRCh38

MGI Vertebrate Homology

Ncbp1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: NCBP1
Gene Tree

Ncbp1

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Endonuclease-mediated

6
Gene trapped

10
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

88
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

13
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ncbp1

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All Sequences

49
RefSeq

8
UniProt

2
CCDS

CCDS18145.1

Ensembl

ENSMUSG00000028330 (Evidence)
NCBI Gene

433702

			Length	Strain/Species	Flank
genomic	433702	NCBI Gene Model \| MGI Sequence Detail	33672	C57BL/6J	± kb
transcript	NM_001033201	RefSeq \| MGI Sequence Detail	2876	C57BL/6
polypeptide	Q3UYV9	UniProt \| EBI \| MGI Sequence Detail	790	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000011026 nuclear cap-binding protein subunit 1

(term hierarchy)
PDB

3UKZ, 3UL0
InterPro Domains

IPR016024 Armadillo-type fold

IPR015172 MIF4G-like, type 1

IPR015174 MIF4G-like, type 2

IPR003890 MIF4G-like, type 3

IPR027159 Nuclear cap-binding protein subunit 1
GlyGen

Q3UYV9 1 site, 1 O-linked glycan (1 site)

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All nucleic 13

cDNA 13

Microarray probesets 3

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MGI:2140419, MGI:2140583

Summaries

All 47

Developmental Gene Expression 1

Gene Ontology 17

Phenotypes 10
Earliest

J:34628 Chadwick BP, et al., Nuclear cap binding protein maps close to the xeroderma pigmentosum complementation group A (XPA) locus in human and mouse. Genomics. 1996 1;35(3):632-3
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ncbp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr37109	Chr4:46138484-46138521 (+)	-229 bp
Tssr37110	Chr4:46138529-46138558 (+)	-188 bp
Tssr37111	Chr4:46138577-46138594 (+)	-146 bp
Tssr37112	Chr4:46138712-46138794 (+)	21 bp
Tssr37113	Chr4:46138821-46138832 (+)	95 bp
Tssr37114	Chr4:46166053-46166064 (+)	27,327 bp
Tssr37115	Chr4:46166068-46166076 (+)	27,340 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29