Miox MGI Mouse Gene Detail - MGI:1891725

Symbol

Miox
Name

myo-inositol oxygenase
Synonyms

0610009I10Rik, Aldrl6, C85427, RSOR

Feature Type

protein coding gene
IDs

MGI:1891725
NCBI Gene: 56727
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr15:89218676-89221210 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 44.82 cM
Mapping Data

2 experiments

SNPs within 2kb

146 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891725	protein coding gene	Chr15:89218601-89221218 (+)
129S1/SvImJ	ENSMUSG00200034056	protein coding gene	Chr15:86370741-86373358 (+)
A/J	ENSMUSG00195019485	protein coding gene	Chr15:86292187-86294804 (+)
AKR/J	ENSMUSG00220028688	protein coding gene	Chr15:86322769-86325386 (+)
BALB/cJ	ENSMUSG00180014324	protein coding gene	Chr15:86145992-86148609 (+)
C3H/HeJ	ENSMUSG00175025564	protein coding gene	Chr15:86478791-86481408 (+)
C57BL/6NJ	ENSMUSG00215019319	protein coding gene	Chr15:86239530-86242147 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020161	protein coding gene	Chr15:83283453-83286051 (+)
CAST/EiJ	ENSTCUG00005029844	protein coding gene	Chr15:85744156-85746773 (+)
CBA/J	ENSMUSG00210012989	protein coding gene	Chr15:86248232-86250849 (+)
DBA/2J	ENSMUSG00185021237	protein coding gene	Chr15:86260171-86262788 (+)
FVB/NJ	ENSMUSG00205021967	protein coding gene	Chr15:86020890-86023507 (+)
JF1/MsJ	ENSUMUG00000035969	protein coding gene	Chr15:85827214-85829836 (+)
LP/J	ENSMUSG00230041774	protein coding gene	Chr15:89610929-89613546 (+)
NOD/ShiLtJ	ENSMUSG00190026847	protein coding gene	Chr15:86264651-86267268 (+)
NZO/HlLtJ	ENSMUSG00225050011	protein coding gene	Chr15:89927271-89929888 (+)
PWK/PhJ	ENSLUMG00010030871	protein coding gene	Chr15:85979814-85982431 (+)
SPRET/EiJ	ENSMSPG00010012957	protein coding gene	Chr15:87681815-87684394 (+)
WSB/EiJ	ENSIUOG00005010735	protein coding gene	Chr15:86354901-86357518 (+)

Human Ortholog

MIOX, myo-inositol oxygenase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MIOX, myo-inositol oxygenase
Synonyms

ALDRL6
Links

HGNC:14522

NCBI Gene ID: 55586

UniProt: Q9UGB7
Chr Location

22q13.33; chr22:50486784-50490648 (+) GRCh38

MGI Vertebrate Homology

Miox stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MIOX
Gene Tree

Miox

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
33 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

5
Radiation induced

2
Targeted

2
Genomic Mutations

3 involving Miox
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

40 strains or lines available

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All GO Annotations

26
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

750
Tissues

106
cDNA Data

205
Literature Summary

4

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase miox

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All Sequences

45
RefSeq

2
UniProt

2
CCDS

CCDS27745.1

Ensembl

ENSMUSG00000022613 (Evidence)
NCBI Gene

56727

			Length	Strain/Species	Flank
genomic	56727	NCBI Gene Model \| MGI Sequence Detail	2535	C57BL/6J	± kb
transcript	NM_019977	RefSeq \| MGI Sequence Detail	1074	FVB/N
polypeptide	Q9QXN5	UniProt \| EBI \| MGI Sequence Detail	285	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000010417 inositol oxygenase

(term hierarchy)
PDB

2HUO, 3BXD
EC

1.13.99.1
InterPro Domains

IPR018170 Aldo/keto reductase, conserved site

IPR007828 Inositol oxygenase
GlyGen

Q9QXN5 1 site, 1 O-linked glycan (1 site)

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All nucleic 205

cDNA 205

Antibodies 1

Microarray probesets 3

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MGI:1915595, MGI:2145970, MGI:2146309

Summaries

All 76

Developmental Gene Expression 4

Diseases 1

Gene Ontology 10

Phenotypes 33
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)

TSS for Miox:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132656	Chr15:89218656-89218675 (+)	-10 bp
Tssr132657	Chr15:89219173-89219182 (+)	502 bp
Tssr132658	Chr15:89219189-89219220 (+)	529 bp
Tssr132659	Chr15:89220219-89220228 (+)	1,548 bp
Tssr4688	Chr15:89221056-89221065 (+)	2,385 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24