Myl10 Gene Detail

Summary

• Symbol
  Myl10
• Name
  myosin, light chain 10, regulatory
• Synonyms
  1700027I08Rik, Mylc2pl, PLRLC, PLRLC-A, PLRLC-B, PLRLC-C

• Feature Type
  protein coding gene
• IDs
  MGI:1891705
  NCBI Gene: 59310
• Alliance
  gene page
• Transcription Start Sites
  20 TSS

Location &
Maps

• Sequence Map
  Chr5:136722000-136729948 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 5, 76.03 cM, cytoband G1
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  473 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891705	protein coding gene	Chr5:136717749-136730711 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030207	protein coding gene	Chr5:141366073-141375985 (+)
A/J	MGP_AJ_G0030175	protein coding gene	Chr5:135262866-135270494 (+)
AKR/J	MGP_AKRJ_G0030108	protein coding gene	Chr5:139630158-139643200 (+)
BALB/cJ	MGP_BALBcJ_G0030185	protein coding gene	Chr5:136617818-136625909 (+)
C3H/HeJ	MGP_C3HHeJ_G0029901	protein coding gene	Chr5:140249470-140257128 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032461	protein coding gene	Chr7:30236858-30240173 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027858	protein coding gene	Chr5:129542884-129549176 (+)
CAST/EiJ	MGP_CASTEiJ_G0029311	protein coding gene	Chr5:139653283-139663281 (+)
CBA/J	MGP_CBAJ_G0029871	protein coding gene	Chr5:152312638-152323741 (+)
DBA/2J	MGP_DBA2J_G0030022	protein coding gene	Chr5:135158807-135166466 (+)
FVB/NJ	MGP_FVBNJ_G0029977	protein coding gene	Chr5:134331280-134338919 (+)
LP/J	MGP_LPJ_G0030111	protein coding gene	Chr5:141791026-141800432 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030009	protein coding gene	Chr5:155270606-155278258 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030678	protein coding gene	Chr5:139456885-139464884 (+)
PWK/PhJ	MGP_PWKPhJ_G0029024	protein coding gene	Chr5:134237896-134246281 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028860	protein coding gene	Chr5:137035935-137043674 (+)
WSB/EiJ	MGP_WSBEiJ_G0029384	protein coding gene	Chr5:140187669-140197498 (+)

Homology

• Human Ortholog
  MYL10, myosin light chain 10

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  MYL10, myosin light chain 10
  
• Synonyms
  MYLC2PL, PLRLC
• Links
  HGNC:29825

  NCBI Gene ID: 93408

  UniProt: Q9BUA6

  
  
• Chr Location
  7q22.1; chr7:101613330-101629296 (-)  GRCh38

---

• MGI Vertebrate Homology
  Myl10 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: MYL10
• Gene Tree
  Myl10
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  3 phenotype references
  

• All Mutations and Alleles
  2
• Endonuclease-mediated
  1
• Targeted
  1
• Find Mice (IMSR)
  39 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  6
• GO References
  4

Expression

• Assay Results
  706
• cDNA Data
  4

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase myl10
  ZFIN myl10

Sequences &
Gene Models

• All Sequences
  52
• RefSeq
  12
• UniProt
  4
• CCDS
  CCDS51668.1, CCDS80433.1, CCDS80434.1

• Ensembl
  ENSMUSG00000005474 (Evidence)
• NCBI Gene
  59310

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000005474	Ensembl Gene Model | MGI Sequence Detail	7949	C57BL/6J
transcript	ENSMUST00000005611	Ensembl | MGI Sequence Detail	688	Not Applicable
polypeptide	ENSMUSP00000005611	Ensembl | MGI Sequence Detail	147	Not Applicable

Protein
Information

• UniProt
  4 Sequences
• Protein Ontology
  PR:000010843 myosin regulatory light chain 10
  (term hierarchy)
• InterPro Domains
  IPR018247 EF-Hand 1, calcium-binding site
  IPR002048 EF-hand domain
  IPR011992 EF-hand domain pair
  IPR050403 Myosin Regulatory Light Chain

Molecular
Reagents

• All nucleic 5

  cDNA 5

  
  

  Microarray probesets 3

Other
Accession IDs

MGI:1917247

References

• Summaries
  All 24

  Gene Ontology 4

  Phenotypes 3
• Earliest
  J:1334 Oltz EM, et al., A novel regulatory myosin light chain gene distinguishes pre-B cell subsets and is IL-7 inducible. EMBO J. 1992 Jul;11(7):2759-67
• Latest
  J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Myl10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr49256	Chr5:136720374-136720383 (+)	-1,621 bp
Tssr49257	Chr5:136721674-136721691 (+)	-317 bp
Tssr49258	Chr5:136721810-136721824 (+)	-183 bp
Tssr49259	Chr5:136721873-136721884 (+)	-121 bp
Tssr49260	Chr5:136721938-136721958 (+)	-52 bp
Tssr49261	Chr5:136722450-136722466 (+)	458 bp
Tssr49262	Chr5:136722468-136722496 (+)	482 bp
Tssr49263	Chr5:136722511-136722516 (+)	514 bp
Tssr49264	Chr5:136722521-136722537 (+)	529 bp
Tssr49265	Chr5:136722975-136722988 (+)	982 bp
Tssr49266	Chr5:136722997-136723003 (+)	1,000 bp
Tssr49267	Chr5:136723067-136723109 (+)	1,088 bp
Tssr49268	Chr5:136724045-136724057 (+)	2,051 bp
Tssr49269	Chr5:136724058-136724067 (+)	2,063 bp
Tssr49270	Chr5:136724069-136724085 (+)	2,077 bp
Tssr49271	Chr5:136724094-136724100 (+)	2,097 bp
Tssr49272	Chr5:136726659-136726664 (+)	4,662 bp
Tssr49273	Chr5:136726673-136726682 (+)	4,678 bp
Tssr49274	Chr5:136726683-136726736 (+)	4,710 bp
Tssr49275	Chr5:136729857-136729863 (+)	7,860 bp