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Syncrip Gene Detail
Summary
  • Symbol
    Syncrip
  • Name
    synaptotagmin binding, cytoplasmic RNA interacting protein
  • Synonyms
    2610109K23Rik, 4632417O19Rik, GRY-RBP, hnRNP Q, Nsap1, Nsap1l, pp68, RRM RNA binding protein GRY-RBP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891690
    NCBI Gene: 56403
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:88331417-88364645 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 47.24 cM, cytoband E3.2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    37 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891690
 protein coding gene Chr9:88329062-88364645 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035109
 protein coding gene Chr9:89324728-89361389 (-)
A/J MGP_AJ_G0035090
 protein coding gene Chr9:86206678-86243565 (-)
AKR/J MGP_AKRJ_G0035018
 protein coding gene Chr9:88221552-88258442 (-)
BALB/cJ MGP_BALBcJ_G0035078
 protein coding gene Chr9:85820107-85856663 (-)
C3H/HeJ MGP_C3HHeJ_G0034790
 protein coding gene Chr9:88699446-88737080 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035602
 protein coding gene Chr9:91734952-91776530 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032508
 protein coding gene Chr9:84929264-84935085 (-)
CAST/EiJ MGP_CASTEiJ_G0034108
 protein coding gene Chr9:89152223-89192525 (-)
CBA/J MGP_CBAJ_G0034763
 protein coding gene Chr9:94948147-94983673 (-)
DBA/2J MGP_DBA2J_G0034921
 protein coding gene Chr9:85732526-85770019 (-)
FVB/NJ MGP_FVBNJ_G0034864
 protein coding gene Chr9:84783209-84820360 (-)
LP/J MGP_LPJ_G0035002
 protein coding gene Chr9:89520557-89560843 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034906
 protein coding gene Chr9:96581015-96624544 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035622
 protein coding gene Chr9:88366042-88402073 (-)
PWK/PhJ MGP_PWKPhJ_G0033812
 protein coding gene Chr9:85885063-85921876 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033648
 protein coding gene Chr9:88539577-88580975 (-)
WSB/EiJ MGP_WSBEiJ_G0034225
 protein coding gene Chr9:88400597-88436487 (-)



Homology
more
  • Human Ortholog
    SYNCRIP, synaptotagmin binding cytoplasmic RNA interacting protein
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SYNCRIP, synaptotagmin binding cytoplasmic RNA interacting protein
  • Synonyms
    GRYRBP, GRY-RBP, hnRNP-Q, HNRNPQ, HNRPQ1, NSAP1, PP68
  • Links
    NCBI Gene ID: 10492
    neXtProt AC: NX_O60506
    UniProt: O60506

  • Chr Location
    6q14.3; chr6:85607779-85644063 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    930
  • Tissues
    147
  • cDNA Data
    27
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56403 NCBI Gene Model | MGI Sequence Detail 33229 C57BL/6J ±  kb
    transcript NM_019796 RefSeq | MGI Sequence Detail 6933 C57BL/6  
    polypeptide Q7TMK9 UniProt | EBI | MGI Sequence Detail 623 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • Protein Ontology
      PR:000015874 heterogeneous nuclear ribonucleoprotein Q
      (term hierarchy)
    • InterPro Domains
      IPR041337 Heterogeneous nuclear ribonucleoprotein Q acidic domain
      IPR034544 Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 1
      IPR034548 Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 2
      IPR006535 HnRNP R/Q splicing factor
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 27
      Primer pair 3
      Other 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1914396, MGI:1925510, MGI:1930916
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 6
      Gene Ontology 11
      Phenotypes 15
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:345319 Herrejon Chavez F, et al., RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells. Nat Commun. 2023 Apr 21;14(1):2290
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory