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Pde4dip Gene Detail
Summary
  • Symbol
    Pde4dip
  • Name
    phosphodiesterase 4D interacting protein (myomegalin)
  • Synonyms
    4732458A06Rik, 9430063L05Rik, D130016K21Rik, D3Bwg1078e, mKIAA0454, Usmg4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891434
    NCBI Gene: 83679
  • Alliance
    genome feature page
  • Transcription Start Sites
    28 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:97597144-97796023 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 42.28 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5982 from dbSNP Build 142
  • Strain Annotations
    37
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891434
 protein coding gene Chr3:97597140-97796023 (-)
129S1/SvImJ ENSMUSGG00200054940
 protein coding gene Chr3:94324398-94352307 (-)
129S1/SvImJ ENSMUSG00200041303
 protein coding gene Chr3:94266519-94295672 (-)
129S1/SvImJ ENSMUSG00200041229
 protein coding gene Chr3:94216877-94218742 (-)
A/J ENSMUSG00195040408
 protein coding gene Chr3:94626815-94628679 (-)
A/J ENSMUSGG00195055035
 protein coding gene Chr3:94734324-94762203 (-)
A/J ENSMUSG00195040445
 protein coding gene Chr3:94676430-94705590 (-)
AKR/J ENSMUSGG00220054496
 protein coding gene Chr3:93086461-93114356 (-)
AKR/J ENSMUSG00220037205
 protein coding gene Chr3:92978942-92980806 (-)
AKR/J ENSMUSG00220037237
 protein coding gene Chr3:93028555-93057712 (-)
BALB/cJ ENSMUSG00180033937
 protein coding gene Chr3:94623117-94652279 (-)
BALB/cJ ENSMUSGG00180055161
 protein coding gene Chr3:94680993-94708895 (-)
BALB/cJ ENSMUSG00180033924
 protein coding gene Chr3:94573503-94575367 (-)
C3H/HeJ ENSMUSGG00175054708
 protein coding gene Chr3:94292705-94320580 (-)
C3H/HeJ ENSMUSG00175027286
 protein coding gene Chr3:94234815-94263974 (-)
C3H/HeJ ENSMUSG00175027267
 protein coding gene Chr3:94185202-94187066 (-)
C57BL/6NJ ENSMUSGG00215055312
 protein coding gene Chr3:95062658-95090548 (-)
C57BL/6NJ ENSMUSG00215028621
 protein coding gene Chr3:94955162-94957026 (-)
C57BL/6NJ ENSMUSG00215028888
 protein coding gene Chr3:95004780-95033937 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025405
 protein coding gene Chr3:91749083-91948031 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210050514
 protein coding gene Chr3:94738209-94740073 (-)
CBA/J ENSMUSGG00210055010
 protein coding gene Chr3:94845716-94873576 (-)
CBA/J ENSMUSG00210050548
 protein coding gene Chr3:94787823-94816980 (-)
DBA/2J ENSMUSGG00185057526
 protein coding gene Chr3:95302951-95330835 (-)
DBA/2J ENSMUSG00185037764
 protein coding gene Chr3:95245051-95274210 (-)
DBA/2J ENSMUSG00185037742
 protein coding gene Chr3:95195444-95197308 (-)
FVB/NJ ENSMUSGG00205054063
 protein coding gene Chr3:93959267-93987165 (-)
FVB/NJ ENSMUSG00205013127
 protein coding gene Chr3:93901398-93930550 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230042534
 protein coding gene Chr3:97148622-97150487 (-)
LP/J ENSMUSGG00230055838
 protein coding gene Chr3:97256134-97284027 (-)
LP/J ENSMUSG00230042635
 protein coding gene Chr3:97198265-97227418 (-)
NOD/ShiLtJ ENSMUSG00190036655
 protein coding gene Chr3:95422263-95451371 (-)
NOD/ShiLtJ ENSMUSGG00190055002
 protein coding gene Chr3:95480023-95507830 (-)
NZO/HlLtJ ENSMUSG00225011513
 protein coding gene Chr3:99675713-99704874 (-)
NZO/HlLtJ ENSMUSG00225011465
 protein coding gene Chr3:99626113-99627977 (-)
NZO/HlLtJ ENSMUSGG00225055554
 protein coding gene Chr3:99733601-99761499 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010036090
 protein coding gene Chr3:94376766-94578146 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    PDE4DIP, phosphodiesterase 4D interacting protein
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDE4DIP, phosphodiesterase 4D interacting protein
  • Synonyms
    CMYA2, MMGL
  • Links
    NCBI Gene ID: 9659
    UniProt: Q5VU43

  • Chr Location
    1q21.2; chr1:148808140-149048286 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit partial (in utero or perinatal) lethality, hyperactivity, and increased vertical activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    799
  • Tissues
    164
  • cDNA Data
    175
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 83679 NCBI Gene Model | MGI Sequence Detail 198880 C57BL/6J ±  kb
    transcript NM_001039376 RefSeq | MGI Sequence Detail 8420 ZRU/MplStud  
    polypeptide Q80YT7 UniProt | EBI | MGI Sequence Detail 2224 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • InterPro Domains
      IPR042791 CDK5 regulatory subunit-associated protein 2
      IPR056273 CDK5 regulatory subunit-associated protein 2/Myomegalin, coiled coil
      IPR012943 Centrosomin, N-terminal motif 1
      IPR052593 Myomegalin/centrosomin
      IPR060527 Myomegalin-like, C-terminal
      IPR010630 Olduvai domain
      IPR040947 Short myomegalin-like EB1 binding protein, N-terminal
      IPR012934 Zinc finger, AD-type
    • GlyGen
      Q80YT7 3 sites, 3 N-linked glycans (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 182
      cDNA 178
      Primer pair 3
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-34220, MGI:106526, MGI:1924553, MGI:2140100, MGI:2442981, MGI:2443905
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 8
      Phenotypes 16
    • Earliest
      J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory