Cep41 MGI Mouse Gene Detail - MGI:1891414

Symbol

Cep41
Name

centrosomal protein 41
Synonyms

1700017E11Rik, 2810431D15Rik, Cep41, Tsga14

Feature Type

protein coding gene
IDs

MGI:1891414
NCBI Gene: 83922
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr6:30653456-30693748 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 12.52 cM
Mapping Data

3 experiments

SNPs within 2kb

164 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891414	protein coding gene	Chr6:30653456-30710511 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030543	protein coding gene	Chr6:28555639-28596012 (-)
A/J	MGP_AJ_G0030516	protein coding gene	Chr6:27325874-27369190 (-)
AKR/J	MGP_AKRJ_G0030443	protein coding gene	Chr6:28240359-28281900 (-)
BALB/cJ	MGP_BALBcJ_G0030526	protein coding gene	Chr6:27473658-27514037 (-)
C3H/HeJ	MGP_C3HHeJ_G0030239	protein coding gene	Chr6:28231373-28272590 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030980	protein coding gene	Chr6:29358032-29400100 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028191	protein coding gene	Chr6:25517889-25558555 (-)
CAST/EiJ	MGP_CASTEiJ_G0029641	protein coding gene	Chr6:28047467-28090613 (-)
CBA/J	MGP_CBAJ_G0030217	protein coding gene	Chr6:30486666-30526608 (-)
DBA/2J	MGP_DBA2J_G0030361	protein coding gene	Chr6:27256389-27299740 (-)
FVB/NJ	MGP_FVBNJ_G0030315	protein coding gene	Chr6:27017387-27061212 (-)
LP/J	MGP_LPJ_G0030448	protein coding gene	Chr6:28686176-28726100 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030351	protein coding gene	Chr6:32918827-32958799 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031010	protein coding gene	Chr6:28112801-28154420 (-)
PWK/PhJ	MGP_PWKPhJ_G0029355	protein coding gene	Chr6:26831360-26872478 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029191	protein coding gene	Chr6:27857652-27902193 (-)
WSB/EiJ	MGP_WSBEiJ_G0029717	protein coding gene	Chr6:28084151-28125873 (-)

Human Ortholog

CEP41, centrosomal protein 41

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CEP41, centrosomal protein 41
Synonyms

JBTS15, TSGA14
Links

HGNC:12370

NCBI Gene ID: 95681

neXtProt AC: NX_Q9BYV8

UniProt: Q9BYV8
Chr Location

7q32.2; chr7:130393771-130441210 (-) GRCh38.p7

Alliance of Genome Resources

Cep41 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CEP41
Gene Tree

Cep41

Diseases

1 with human CEP41 associations

				Human Disease	Mouse Models
				Joubert syndrome 15 IDs Joubert syndrome 15 DOID:0110984 OMIM:614464

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Gene trapped

5
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous disruption of this gene causes an abnormal gait, increased thermal nociceptive threshold, and alterations in fertility/fecundity and eye morphology. Some embryos homozygous for a gene trapped allele die at E10-E12 exhibiting turning failure, dilated pericardial sacs, and brain anomalies.

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All GO Annotations

17
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

728
Tissues

1
cDNA Data

43
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cep41

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Cep41 interacts with 361 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

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All Sequences

85
RefSeq

20
UniProt

8
CCDS

CCDS19978.1

Ensembl

ENSMUSG00000029790 (Evidence)
NCBI Gene

83922

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029790	Ensembl Gene Model \| MGI Sequence Detail	40293	C57BL/6J	± kb
transcript	ENSMUST00000031810	Ensembl \| MGI Sequence Detail	3447	Not Applicable
polypeptide	ENSMUSP00000031810	Ensembl \| MGI Sequence Detail	373	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000016723 centrosomal protein of 41 kDa

(term hierarchy)
InterPro Domains

IPR001763 Rhodanese-like domain

IPR036873 Rhodanese-like domain superfamily

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All nucleic 43

cDNA 43

Microarray probesets 6

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MGI:1889830, MGI:1916627, MGI:1925624, MGI:2141435

Summaries

All 39

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 10
Earliest

J:61896 Lee YJ, et al., Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1). FEBS Lett. 2000 Apr 28;472(2-3):230-4
Latest

J:182289 Ishikawa H, et al., Proteomic analysis of mammalian primary cilia. Curr Biol. 2012 Mar 6;22(5):414-9

TSS for Cep41:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr60138	Chr6:30693676-30693736 (-)	42 bp
Tssr1804	Chr6:30680502-30680514 (-)	13,240 bp
Tssr60137	Chr6:30669497-30669500 (-)	24,249 bp
Tssr60136	Chr6:30669457-30669460 (-)	24,289 bp
Tssr60135	Chr6:30669442-30669449 (-)	24,302 bp
Tssr60134	Chr6:30669377-30669411 (-)	24,354 bp
Tssr60133	Chr6:30669310-30669321 (-)	24,432 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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