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Onecut3 Gene Detail
Summary
  • Symbol
    Onecut3
  • Name
    one cut domain, family member 3
  • Synonyms
    Oc3, OC-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891409
    NCBI Gene: 246086
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:80330740-80353100 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    546 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891409
 protein coding gene Chr10:80330669-80353110 (+)
129S1/SvImJ ENSMUSG00200046348
 protein coding gene Chr10:76956675-76979117 (+)
A/J ENSMUSG00195048093
 protein coding gene Chr10:77352226-77374681 (+)
AKR/J ENSMUSG00220045138
 protein coding gene Chr10:76949904-76972362 (+)
BALB/cJ ENSMUSG00180052454
 protein coding gene Chr10:77362681-77385130 (+)
C3H/HeJ ENSMUSG00175047545
 protein coding gene Chr10:77233469-77255919 (+)
C57BL/6NJ ENSMUSG00215048596
 protein coding gene Chr10:76975266-76997713 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015586
 protein coding gene Chr10:74492457-74513984 (+)
CAST/EiJ ENSTCUG00005051078
 protein coding gene Chr10:76861195-76883878 (+)
CBA/J ENSMUSG00210037217
 protein coding gene Chr10:77089505-77111952 (+)
DBA/2J ENSMUSG00185052908
 protein coding gene Chr10:77431927-77454371 (+)
FVB/NJ ENSMUSG00205049029
 protein coding gene Chr10:77144686-77167134 (+)
JF1/MsJ ENSUMUG00000049200
 protein coding gene Chr10:78664240-78686703 (+)
LP/J ENSMUSG00230048495
 protein coding gene Chr10:79201554-79223999 (+)
NOD/ShiLtJ ENSMUSG00190051955
 protein coding gene Chr10:77345663-77368113 (+)
NZO/HlLtJ ENSMUSG00225051680
 protein coding gene Chr10:83488061-83510510 (+)
PWK/PhJ ENSLUMG00010042536
 protein coding gene Chr10:77025531-77047948 (+)
SPRET/EiJ ENSMSPG00010041628
 protein coding gene Chr10:78640367-78661162 (+)
WSB/EiJ ENSIUOG00005048381
 protein coding gene Chr10:77049697-77072078 (+)



Homology
more
  • Human Ortholog
    ONECUT3, one cut homeobox 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ONECUT3, one cut homeobox 3
  • Synonyms
    OC3
  • Links
    NCBI Gene ID: 390874
    UniProt: O60422

  • Chr Location
    19p13.3; chr19:1753506-1780988 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    7 phenotype references
Mice homozygous for a reporter/null allele display normal pancreas and gut development with no apparent alterations in enteroendocrine differentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    878
  • Tissues
    157
  • cDNA Data
    4
  • Literature Summary
    24
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 246086 NCBI Gene Model | MGI Sequence Detail 22361 C57BL/6J ±  kb
transcript NM_139226 RefSeq | MGI Sequence Detail 4705 C57BL/6  
polypeptide Q8K557 UniProt | EBI | MGI Sequence Detail 490 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 4
    Primer pair 3
    Antibodies 1

    Microarray probesets 2
References
more
  • Summaries
    All 49
    Developmental Gene Expression 24
    Gene Ontology 7
    Phenotypes 7
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:357897 Renaux E, et al., Arid3c identifies an uncharacterized subpopulation of V2 interneurons during embryonic spinal cord development. Front Cell Neurosci. 2024;18:1466056
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory