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Ap1s3 Gene Detail
Summary
  • Symbol
    Ap1s3
  • Name
    adaptor-related protein complex AP-1, sigma 3
  • Synonyms
    Jr2, [s]3A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891304
    NCBI Gene: 252903
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:79584593-79649689 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 40.92 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2024 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891304
 protein coding gene Chr1:79584593-79649736 (-)
129S1/SvImJ ENSMUSG00200034268
 protein coding gene Chr1:77263413-77325761 (-)
A/J ENSMUSG00195009716
 protein coding gene Chr1:76675374-76737763 (-)
AKR/J ENSMUSG00220010031
 protein coding gene Chr1:76846549-76911666 (-)
BALB/cJ ENSMUSG00180019469
 protein coding gene Chr1:76937890-77000283 (-)
C3H/HeJ ENSMUSG00175017725
 protein coding gene Chr1:77081900-77144295 (-)
C57BL/6NJ ENSMUSG00215013401
 protein coding gene Chr1:76987030-77052139 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014316
 protein coding gene Chr1:72936490-72999292 (-)
CAST/EiJ ENSTCUG00005026067
 protein coding gene Chr1:76651078-76713145 (-)
CBA/J ENSMUSG00210038595
 protein coding gene Chr1:76864995-76927404 (-)
DBA/2J ENSMUSG00185028475
 protein coding gene Chr1:77911155-77973573 (-)
FVB/NJ ENSMUSG00205027943
 protein coding gene Chr1:76394624-76456939 (-)
JF1/MsJ ENSUMUG00000004093
 protein coding gene Chr1:76698959-76768509 (-)
LP/J ENSMUSG00230009301
 protein coding gene Chr1:77838677-77901015 (-)
NOD/ShiLtJ ENSMUSG00190036592
 protein coding gene Chr1:77068649-77131058 (-)
NZO/HlLtJ ENSMUSG00225039865
 protein coding gene Chr1:81074034-81136423 (-)
PWK/PhJ ENSLUMG00010012485
 protein coding gene Chr1:76314165-76377318 (-)
SPRET/EiJ ENSMSPG00010019024
 protein coding gene Chr1:78485942-78554101 (-)
WSB/EiJ ENSIUOG00005013539
 protein coding gene Chr1:76605961-76670836 (-)



Homology
more
  • Human Ortholog
    AP1S3, adaptor related protein complex 1 subunit sigma 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AP1S3, adaptor related protein complex 1 subunit sigma 3
  • Synonyms
    PSORS15, sigma1C
  • Links
    NCBI Gene ID: 130340
    UniProt: Q96PC3

  • Chr Location
    2q36.1; chr2:223667680-223838027 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human AP1S3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Ap1s3
  • Find Mice (IMSR)
    18 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    616
  • Tissues
    7
  • cDNA Data
    19
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054702 Ensembl Gene Model | MGI Sequence Detail 65097 C57BL/6J ±  kb
transcript ENSMUST00000162342 Ensembl | MGI Sequence Detail 2876 Not Applicable  
polypeptide ENSMUSP00000125268 Ensembl | MGI Sequence Detail 154 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    Genomic 1
    cDNA 19
    Primer pair 2

    Microarray probesets 2
References
more
  • Summaries
    All 45
    Developmental Gene Expression 4
    Gene Ontology 8
    Phenotypes 13
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory