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Gabarapl2 Gene Detail
Summary
  • Symbol
    Gabarapl2
  • Name
    GABA type A receptor associated protein like 2
  • Synonyms
    0610012F20Rik, 2900019O08Rik, GATE-16, Gef2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890602
    NCBI Gene: 93739
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:112667335-112679547 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 58.19 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    107 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890602
 protein coding gene Chr8:112667335-112680244 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034150
 protein coding gene Chr8:114776794-114790979 (+)
A/J MGP_AJ_G0034130
 protein coding gene Chr8:110089496-110105308 (+)
AKR/J MGP_AKRJ_G0034057
 protein coding gene Chr8:113332640-113347597 (+)
BALB/cJ MGP_BALBcJ_G0034124
 protein coding gene Chr8:110268353-110281274 (+)
C3H/HeJ MGP_C3HHeJ_G0033835
 protein coding gene Chr8:114041940-114056034 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034644
 protein coding gene Chr8:118782623-118797371 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031586
 protein coding gene Chr8:103161015-103176301 (+)
CAST/EiJ MGP_CASTEiJ_G0033162
 protein coding gene Chr8:113688874-113702031 (+)
CBA/J MGP_CBAJ_G0033808
 protein coding gene Chr8:122882085-122894952 (+)
DBA/2J MGP_DBA2J_G0033964
 protein coding gene Chr8:109363220-109376035 (+)
FVB/NJ MGP_FVBNJ_G0033907
 protein coding gene Chr8:108345228-108357589 (+)
LP/J MGP_LPJ_G0034053
 protein coding gene Chr8:114932691-114945745 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033954
 protein coding gene Chr8:125711326-125726225 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034662
 protein coding gene Chr8:113318882-113334262 (+)
PWK/PhJ MGP_PWKPhJ_G0032864
 protein coding gene Chr8:108977184-108992068 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032704
 protein coding gene Chr8:111975216-111985240 (+)
WSB/EiJ MGP_WSBEiJ_G0033278
 protein coding gene Chr8:114000930-114017184 (+)



Homology
more
  • Human Ortholog
    GABARAPL2, GABA type A receptor associated protein like 2
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GABARAPL2, GABA type A receptor associated protein like 2
  • Synonyms
    ATG8, ATG8C, GATE16, GATE-16, GEF2, GEF-2
  • Links
    NCBI Gene ID: 11345
    neXtProt AC: NX_P60520
    UniProt: P60520

  • Chr Location
    16q23.1; chr16:75566375-75577881 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    767
  • Tissues
    47
  • cDNA Data
    12
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 93739 NCBI Gene Model | MGI Sequence Detail 12213 C57BL/6J ±  kb
    transcript NM_026693 RefSeq | MGI Sequence Detail 996 C57BL/6  
    polypeptide P60521 UniProt | EBI | MGI Sequence Detail 117 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000007759 gamma-aminobutyric acid receptor-associated protein-like 2
      (term hierarchy)
    • InterPro Domains
      IPR004241 Autophagy protein Atg8 ubiquitin-like
      IPR029071 Ubiquitin-like domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 12
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1861743, MGI:1915608, MGI:1920098, MGI:2142469
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 12
    • Earliest
      J:63409 Kneussel M, et al., The gamma-aminobutyric acid type A receptor (GABAAR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8594-9
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory