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Srsf4 Gene Detail
Summary
  • Symbol
    Srsf4
  • Name
    serine and arginine-rich splicing factor 4
  • Synonyms
    5730499P16Rik, MNCb-2616, Sfrs4, SRp75
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890577
    NCBI Gene: 57317
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:131600928-131629017 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 64.53 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    450 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890577
 protein coding gene Chr4:131600841-131629036 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028859
 protein coding gene Chr4:133987983-134015906 (+)
A/J MGP_AJ_G0028818
 protein coding gene Chr4:128419996-128446982 (+)
AKR/J MGP_AKRJ_G0028771
 protein coding gene Chr4:132015775-132044090 (+)
BALB/cJ MGP_BALBcJ_G0028841
 protein coding gene Chr4:129033020-129060810 (+)
C3H/HeJ MGP_C3HHeJ_G0028555
 protein coding gene Chr4:132267904-132295149 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029283
 protein coding gene Chr4:138802121-138831483 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026555
 protein coding gene Chr4:121514528-121542632 (+)
CAST/EiJ MGP_CASTEiJ_G0027988
 protein coding gene Chr4:130334324-130363540 (+)
CBA/J MGP_CBAJ_G0028521
 protein coding gene Chr4:142345159-142378035 (+)
DBA/2J MGP_DBA2J_G0028670
 protein coding gene Chr4:128843555-128870843 (+)
FVB/NJ MGP_FVBNJ_G0028637
 protein coding gene Chr4:127694366-127721359 (+)
LP/J MGP_LPJ_G0028771
 protein coding gene Chr4:134144507-134173156 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028663
 protein coding gene Chr4:146989808-147018786 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029321
 protein coding gene Chr4:132409185-132439989 (+)
PWK/PhJ MGP_PWKPhJ_G0027709
 protein coding gene Chr4:125512704-125540257 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027535
 protein coding gene Chr4:128295986-128323269 (+)
WSB/EiJ MGP_WSBEiJ_G0028068
 protein coding gene Chr4:132589693-132618944 (+)



Homology
more
  • Human Ortholog
    SRSF4, serine and arginine rich splicing factor 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SRSF4, serine and arginine rich splicing factor 4
  • Synonyms
    SFRS4, SRP75
  • Links
    NCBI Gene ID: 6429
    neXtProt AC: NX_Q08170
    UniProt: Q08170

  • Chr Location
    1p35.3; chr1:29147743-29181900 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    728
  • Tissues
    22
  • cDNA Data
    10
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028911 Ensembl Gene Model | MGI Sequence Detail 28090 C57BL/6J ±  kb
    transcript ENSMUST00000053819 Ensembl | MGI Sequence Detail 2257 Not Applicable  
    polypeptide ENSMUSP00000061474 Ensembl | MGI Sequence Detail 491 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000014761 serine/arginine-rich splicing factor 4
      (term hierarchy)
    • InterPro Domains
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
      IPR050374 RRT5/SRSF/Splicing Factor SR
      IPR047190 Serine/arginine-rich splicing factor 4 (SRSF4)-like, RNA recognition motif 2
    • GlyGen
      Q8VE97 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1913899, MGI:2140593
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 18
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory