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Vps35 Gene Detail
Summary
  • Symbol
    Vps35
  • Name
    VPS35 retromer complex component
  • Synonyms
    Mem3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890467
    NCBI Gene: 65114
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:85987014-86026146 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 41.61 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    953 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890467
 protein coding gene Chr8:85987014-86026431 (-)
129S1/SvImJ ENSMUSG00200016717
 protein coding gene Chr8:80330066-80369458 (-)
A/J ENSMUSG00195015883
 protein coding gene Chr8:80686396-80725673 (-)
AKR/J ENSMUSG00220034671
 protein coding gene Chr8:80729707-80769104 (-)
BALB/cJ ENSMUSG00180019243
 protein coding gene Chr8:80533450-80572845 (-)
C3H/HeJ ENSMUSG00175024981
 protein coding gene Chr8:80622056-80661334 (-)
C57BL/6NJ ENSMUSG00215027619
 protein coding gene Chr8:80253271-80292683 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031335
 protein coding gene Chr8:76576693-76615737 (-)
CAST/EiJ ENSTCUG00005034364
 protein coding gene Chr8:80137742-80177051 (-)
CBA/J ENSMUSG00210034650
 protein coding gene Chr8:80609177-80648459 (-)
DBA/2J ENSMUSG00185032660
 protein coding gene Chr8:86717771-86757051 (-)
FVB/NJ ENSMUSG00205033738
 protein coding gene Chr8:79665038-79704320 (-)
JF1/MsJ ENSUMUG00000008096
 protein coding gene Chr8:89058947-89098354 (-)
LP/J ENSMUSG00230029017
 protein coding gene Chr8:90327032-90366426 (-)
NOD/ShiLtJ ENSMUSG00190013601
 protein coding gene Chr8:80685744-80725022 (-)
NZO/HlLtJ ENSMUSG00225038403
 protein coding gene Chr8:93744279-93783689 (-)
PWK/PhJ ENSLUMG00010026167
 protein coding gene Chr8:80384877-80424470 (-)
SPRET/EiJ ENSMSPG00010028810
 protein coding gene Chr8:82277935-82320390 (-)
WSB/EiJ ENSIUOG00005017186
 protein coding gene Chr8:81424094-81463489 (-)



Homology
more
  • Human Ortholog
    VPS35, VPS35 retromer complex component
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VPS35, VPS35 retromer complex component
  • Synonyms
    MEM3, PARK17
  • Links
    NCBI Gene ID: 55737
    UniProt: Q96QK1

  • Chr Location
    16q11.2; chr16:46656132-46689518 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Vps35 mouse models; 2 with human VPS35 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 6 alleles in 6 genetic backgrounds
    21 phenotypes from multigenic genotypes
    3 images
    81 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele die prior to E10. Inducible KO in microglia results in reduced damage from ischemic stroke in the cortex. Heterozygosity for a Parkinson's disease associated missense mutation affects mitochondrial function in substantia nigra neurons, which leads to late onset bradykinesia and reduced locomotor activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    143
  • GO References
    28
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    684
  • Tissues
    61
  • cDNA Data
    20
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 65114 NCBI Gene Model | MGI Sequence Detail 39133 C57BL/6J ±  kb
    transcript NM_022997 RefSeq | MGI Sequence Detail 3196 ZRU/MplStud  
    polypeptide Q9EQH3 UniProt | EBI | MGI Sequence Detail 796 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 20
      Primer pair 4
      Other 1
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35082, MGI:106625, MGI:2142604
    References
    more
    • Summaries
      All 144
      Developmental Gene Expression 8
      Diseases 3
      Gene Ontology 28
      Phenotypes 81
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:388813 Barbosa MG, et al., Vacuolar Protein Sorting 35 Controls Hepatocellular Proliferation Through SRC Signaling and Promotes Diethyl Nitrosamine-Induced Tumor Initiation. Cell Mol Gastroenterol Hepatol. 2026 May 5;20(8):101788
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory