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Uchl4 Gene Detail
Summary
  • Symbol
    Uchl4
  • Name
    ubiquitin carboxyl-terminal esterase L4
Location &
Maps
more
  • Sequence Map
    Chr9:64142483-64143644 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 34.58 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    61 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890440
 protein coding gene Chr9:64142483-64143644 (+)
129S1/SvImJ ENSMUSG00200040715
 protein coding gene Chr9:61245043-61246204 (+)
A/J ENSMUSG00195025516
 protein coding gene Chr9:60954668-60955829 (+)
AKR/J ENSMUSG00220033970
 protein coding gene Chr9:61105079-61106240 (+)
BALB/cJ ENSMUSG00180016523
 protein coding gene Chr9:61092734-61093895 (+)
C3H/HeJ ENSMUSG00175011618
 protein coding gene Chr9:61088433-61089594 (+)
C57BL/6NJ ENSMUSG00215029549
 protein coding gene Chr9:61079843-61081004 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032342
 protein coding gene Chr9:61400936-61402245 (+)
CAST/EiJ ENSTCUG00005030032
 protein coding gene Chr9:61000915-61002076 (+)
CBA/J ENSMUSG00210013555
 protein coding gene Chr9:61174932-61176093 (+)
DBA/2J ENSMUSG00185029475
 protein coding gene Chr9:61198145-61199306 (+)
FVB/NJ ENSMUSG00205014674
 protein coding gene Chr9:61525284-61526445 (+)
JF1/MsJ ENSUMUG00000033086
 protein coding gene Chr9:61262755-61263947 (+)
LP/J ENSMUSG00230024040
 protein coding gene Chr9:61444186-61445347 (+)
NOD/ShiLtJ ENSMUSG00190018687
 protein coding gene Chr9:61285047-61286208 (+)
NZO/HlLtJ ENSMUSG00225044660
 protein coding gene Chr9:61509466-61510627 (+)
PWK/PhJ ENSLUMG00010025414
 protein coding gene Chr9:61227620-61228773 (+)
SPRET/EiJ ENSMSPG00010019534
 protein coding gene Chr9:62287024-62288190 (+)
WSB/EiJ ENSIUOG00005024400
 protein coding gene Chr9:60690882-60692043 (+)



Homology
more
  • Human Ortholog
    UCHL3, ubiquitin C-terminal hydrolase L3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UCHL3, ubiquitin C-terminal hydrolase L3
  • Synonyms
    UCH-L3
  • Links
    NCBI Gene ID: 7347
    UniProt: P15374

  • Chr Location
    13q22.2; chr13:75549483-75607472 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    768
  • Tissues
    25
  • cDNA Data
    4
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 93841 NCBI Gene Model | MGI Sequence Detail 1162 C57BL/6J ±  kb
    transcript NM_033607 RefSeq | MGI Sequence Detail 1162 ZRU/MplStud  
    polypeptide P58321 UniProt | EBI | MGI Sequence Detail 233 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000017221 ubiquitin carboxyl-terminal hydrolase isozyme L4
      (term hierarchy)
    • EC
      3.4.19.12
    • InterPro Domains
      IPR038765 Papain-like cysteine peptidase superfamily
      IPR001578 Peptidase C12, ubiquitin carboxyl-terminal hydrolase
      IPR036959 Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamily
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 4
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 28
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 7
    • Earliest
      J:69453 Osawa Y, et al., Cloning, expression, and mapping of a mouse gene, Uchl4, highly homologous to human and mouse Uchl3. Biochem Biophys Res Commun. 2001 May 11;283(3):627-33
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory