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Igf2bp3 Gene Detail
Summary
  • Symbol
    Igf2bp3
  • Name
    insulin-like growth factor 2 mRNA binding protein 3
  • Synonyms
    2610101N11Rik, IMP3, Koc13
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890359
    NCBI Gene: 140488
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:49062157-49191891 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 6, 23.82 cM, cytoband B2.3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    555 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890359
protein coding gene Chr6:49062152-49200225 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030721
protein coding gene Chr6:48070293-48213247 (-)
A/J MGP_AJ_G0030692
protein coding gene Chr6:45878183-46011604 (-)
AKR/J MGP_AKRJ_G0030617
protein coding gene Chr6:47494819-47634142 (-)
BALB/cJ MGP_BALBcJ_G0030702
protein coding gene Chr6:46217099-46347773 (-)
C3H/HeJ MGP_C3HHeJ_G0030415
protein coding gene Chr6:47498299-47641693 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031157
protein coding gene Chr6:49203821-49345105 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028364
protein coding gene Chr6:43490392-43620030 (-)
CAST/EiJ MGP_CASTEiJ_G0029819
protein coding gene Chr6:47223496-47357984 (-)
CBA/J MGP_CBAJ_G0030390
protein coding gene Chr6:51243895-51389552 (-)
DBA/2J MGP_DBA2J_G0030539
protein coding gene Chr6:45790278-45924641 (-)
FVB/NJ MGP_FVBNJ_G0030491
protein coding gene Chr6:45432698-45565947 (-)
LP/J MGP_LPJ_G0030624
protein coding gene Chr6:48052335-48191470 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030525
protein coding gene Chr6:54008348-54154333 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031186
protein coding gene Chr6:47359316-47496607 (-)
PWK/PhJ MGP_PWKPhJ_G0029531
protein coding gene Chr6:45336791-45470964 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029367
protein coding gene Chr6:46704949-46844717 (-)
WSB/EiJ MGP_WSBEiJ_G0029896
protein coding gene Chr6:47359315-47495573 (-)



Homology
more
  • Human Ortholog
    IGF2BP3, insulin like growth factor 2 mRNA binding protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGF2BP3, insulin like growth factor 2 mRNA binding protein 3
  • Synonyms
    CT98, IMP3, IMP-3, KOC, KOC1, VICKZ3
  • Links
    NCBI Gene ID: 10643
    neXtProt AC: NX_O00425
    UniProt: O00425

  • Chr Location
    7p15.3; chr7:23310209-23470491 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029814 Ensembl Gene Model | MGI Sequence Detail 129735 C57BL/6J ±  kb
transcript ENSMUST00000031838 Ensembl | MGI Sequence Detail 4345 Not Applicable  
polypeptide ENSMUSP00000031838 Ensembl | MGI Sequence Detail 579 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    Genomic 3
    cDNA 19
    Primer pair 3
    Other 1

    Microarray probesets 7
Other
Accession IDs
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MGI:1919721, MGI:2141367, MGI:2141534, MGI:2141597
References
more
  • Summaries
    All 58
    Developmental Gene Expression 12
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:30335 Duh JL, et al., The Y-box motif mediates redox-dependent transcriptional activation in mouse cells. J Biol Chem. 1995 Dec 22;270(51):30499-507
  • Latest
    J:346346 Yuan D, et al., IGF2BP3-stabilized CAMK1 regulates the mitochondrial dynamics of renal tubule to alleviate diabetic nephropathy. Biochim Biophys Acta Mol Basis Dis. 2024 Mar;1870(3):167022

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory