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Il17re Gene Detail
Summary
  • Symbol
    Il17re
  • Name
    interleukin 17 receptor E
  • Synonyms
    Il25r
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889371
    NCBI Gene: 57890
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:113435659-113447719 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 6, 52.76 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    458 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889371
protein coding gene Chr6:113435445-113447719 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031125
protein coding gene Chr6:115978714-115992187 (+)
A/J MGP_AJ_G0031094
protein coding gene Chr6:111535549-111547808 (+)
AKR/J MGP_AKRJ_G0031025
protein coding gene Chr6:114529447-114541689 (+)
BALB/cJ MGP_BALBcJ_G0031105
protein coding gene Chr6:111481561-111493817 (+)
C3H/HeJ MGP_C3HHeJ_G0030603
protein coding gene Chr6:69756403-69768903 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031564
protein coding gene Chr6:118983057-118995329 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028728
protein coding gene Chr6:108563250-108575732 (+)
CAST/EiJ MGP_CASTEiJ_G0030212
protein coding gene Chr6:114973923-114987598 (+)
CBA/J MGP_CBAJ_G0030791
protein coding gene Chr6:123678441-123690693 (+)
DBA/2J MGP_DBA2J_G0030944
protein coding gene Chr6:110614958-110627216 (+)
FVB/NJ MGP_FVBNJ_G0030898
protein coding gene Chr6:109617051-109629317 (+)
LP/J MGP_LPJ_G0031024
protein coding gene Chr6:116015403-116027385 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030932
protein coding gene Chr6:127942842-127955109 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031591
protein coding gene Chr6:114543786-114556044 (+)
PWK/PhJ MGP_PWKPhJ_G0029928
protein coding gene Chr6:109570939-109583427 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029756
protein coding gene Chr6:113361273-113374560 (+)
WSB/EiJ MGP_WSBEiJ_G0030296
protein coding gene Chr6:114918657-114930662 (+)



Homology
more
  • Human Ortholog
    IL17RE, interleukin 17 receptor E
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL17RE, interleukin 17 receptor E
  • Links
    NCBI Gene ID: 132014
    neXtProt AC: NX_Q8NFR9
    UniProt: Q8NFR9

  • Chr Location
    3p25.3; chr3:9902093-9916402 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice exhibit increased susceptibility to DSS-induced colitis, imiquimod-induced psoriasis, and C. rodentium bacterial infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 57890 NCBI Gene Model | MGI Sequence Detail 12061 C57BL/6J ±  kb
    transcript NM_001034031 RefSeq | MGI Sequence Detail 2712 C57BL/6  
    polypeptide Q8BH06 UniProt | EBI | MGI Sequence Detail 637 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 38

      Microarray probesets 4
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 23
    • Earliest
      J:87486 Akeson EC, Chromosomal inversion discovered in C3H/HeJ mice. JAX Notes. 2003;491:15
    • Latest
      J:344781 Wang J, et al., Interleukin-17 Receptor E and C-C Motif Chemokine Receptor 10 Identify Heterogeneous T Helper 17 Subsets in a Mouse Dry Eye Disease Model. Am J Pathol. 2022 Feb;192(2):332-343

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/29/2024
    MGI 6.24
    The Jackson Laboratory