Pdss1 MGI Mouse Gene Detail - MGI:1889278 - prenyl (solanesyl) diphosphate synthase, subunit 1

Symbol

Pdss1
Name

prenyl (solanesyl) diphosphate synthase, subunit 1
Synonyms

2610203G20Rik, 2700031G06Rik, mSPS1, Tprt

Feature Type

protein coding gene
IDs

MGI:1889278
NCBI Gene: 56075
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:22785534-22830278 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 15.17 cM, cytoband A3
Mapping Data

2 experiments

SNPs within 2kb

16 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1889278	protein coding gene	Chr2:22784393-22830278 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025393	protein coding gene	Chr2:20630084-20678413 (+)
A/J	MGP_AJ_G0025371	protein coding gene	Chr2:19788613-19834615 (+)
AKR/J	MGP_AKRJ_G0025340	protein coding gene	Chr2:20501423-20549354 (+)
BALB/cJ	MGP_BALBcJ_G0025366	protein coding gene	Chr2:19907116-19952209 (+)
C3H/HeJ	MGP_C3HHeJ_G0025127	protein coding gene	Chr2:20406469-20450566 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025810	protein coding gene	Chr2:21228739-21277392 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023224	protein coding gene	Chr2:18878400-18926653 (+)
CAST/EiJ	MGP_CASTEiJ_G0024590	protein coding gene	Chr2:20331360-20375890 (+)
CBA/J	MGP_CBAJ_G0025105	protein coding gene	Chr2:22040033-22090263 (+)
DBA/2J	MGP_DBA2J_G0025238	protein coding gene	Chr2:19690509-19736551 (+)
FVB/NJ	MGP_FVBNJ_G0025200	protein coding gene	Chr2:19475156-19521194 (+)
LP/J	MGP_LPJ_G0025324	protein coding gene	Chr2:20563861-20610339 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025231	protein coding gene	Chr2:22081323-22131820 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025869	protein coding gene	Chr2:20375727-20430961 (+)
PWK/PhJ	MGP_PWKPhJ_G0024339	protein coding gene	Chr2:19512727-19558272 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024139	protein coding gene	Chr2:20516017-20556978 (+)
WSB/EiJ	MGP_WSBEiJ_G0024660	protein coding gene	Chr2:20531291-20573290 (+)

Human Ortholog

PDSS1, decaprenyl diphosphate synthase subunit 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PDSS1, decaprenyl diphosphate synthase subunit 1
Synonyms

COQ1, COQ10D2, COQ1A, DPS, hDPS1, SPS, TPRT, TPT, TPT 1
Links

HGNC:17759

NCBI Gene ID: 23590

neXtProt AC: NX_Q5T2R2

UniProt: Q5T2R2
Chr Location

10p12.1; chr10:26697701-26746798 (+) GRCh38

MGI Vertebrate Homology

Pdss1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PDSS1
Gene Tree

Pdss1

Diseases

1 with human PDSS1 associations

				Human Disease	Mouse Models
				primary coenzyme Q10 deficiency 2 IDs primary coenzyme Q10 deficiency 2 DOID:0070239 OMIM:614651 ORDO:254898

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Gene trapped

3
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

19
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

806
Tissues

96
cDNA Data

5
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pdss1

ZFIN pdss1

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All Sequences

61
RefSeq

17
UniProt

5
CCDS

CCDS38057.1, CCDS89432.1

Ensembl

ENSMUSG00000026784 (Evidence)
NCBI Gene

56075

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026784	Ensembl Gene Model \| MGI Sequence Detail	44745	C57BL/6J	± kb
transcript	ENSMUST00000053729	Ensembl \| MGI Sequence Detail	1642	Not Applicable
polypeptide	ENSMUSP00000055689	Ensembl \| MGI Sequence Detail	409	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000012521 all trans-polyprenyl-diphosphate synthase PDSS1

(term hierarchy)
EC

2.5.1.91
InterPro Domains

IPR008949 Isoprenoid synthase domain superfamily

IPR000092 Polyprenyl synthetase

IPR033749 Polyprenyl synthetase, conserved site

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All nucleic 9

cDNA 8

Primer pair 1

Microarray probesets 3

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MGI:1914443, MGI:1919716

Summaries

All 36

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:305946 Xu M, et al., The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development. Development. 2021 Apr 15;148(8):dev199026

TSS for Pdss1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr16522	Chr2:22785494-22785497 (+)	-38 bp
Tssr16523	Chr2:22785571-22785580 (+)	42 bp
Tssr16524	Chr2:22785595-22785641 (+)	84 bp
Tssr16525	Chr2:22804675-22804694 (+)	19,151 bp
Tssr16526	Chr2:22818569-22818574 (+)	33,038 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23